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Volume 21, Number 12—December 2015
Dispatch

Replication Capacity of Avian Influenza A(H9N2) Virus in Pet Birds and Mammals, Bangladesh

Brian J. Lenny, Karthik Shanmuganatham, Stephanie Sonnberg, Mohammed M. Feeroz, S.M. Rabiul Alam, M. Kamrul Hasan, Lisa Jones-Engel, Pamela McKenzie, Scott Krauss, Robert G. Webster, and Jeremy C. JonesComments to Author 
Author affiliations: Rhodes College, Memphis, Tennessee, USA (B.J. Lenny); St. Jude Children’s Research Hospital, Memphis (B.J. Lenny, K. Shanmuganatham, S. Sonnberg, P. McKenzie, S. Krauss, R.G. Webster, J.C. Jones); Jahangirnagar University, Dhaka, Bangladesh (M.M. Feeroz, S.M.R. Alam, M.K. Hasan); University of Washington, Seattle, Washington, USA (L. Jones-Engel)

Main Article

Table 1

Replication of avian influenza A(H9N2) virus in organs and seroconversion of inoculated birds, Bangladesh*

Bird Organ titer†
HI titer‡
Brain Eye Trachea Lung Small intestine Large intestine Donor Contact
Finch 2.9 (2/3) 3.5 (1/3) 3 (2/3) 3.5 (1/3) 4.3 (1/5) – (0/5)
Parakeet ND ND 3.5 (1/3) ­– 6.1 (4/5) 5.3 (1/5)
Chicken 5.5 (1/1) 4.25 (1/1) 4.5 (3/3) 5.1 (3/3) 3 (2/3) 4.5 (1/3) 10.8 (6/6) 10.9 (4/4)

*HI, hemagglutination inhibition; –, below the limit of detection (<0.75 50% egg infectious doses [EID50]/mL or serum dilution <1:20); ND, not determined.
†Tissues were harvested 3 days postinoculation and titrated in embryonated chicken eggs, and were reported as log10 EID50/mL. Data are the means of positive samples (>0.75 EID50/mL) (no. birds shedding/total birds sampled at given time point).
‡Mean reciprocal values (log2/50μL) of the highest titer that inhibited 4 hemagglutinating units of homologous virus (no. seropositive animals/total no. sampled).

Main Article

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Page created: November 17, 2015
Page updated: November 17, 2015
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