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Volume 21, Number 4—April 2015

Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

Emmie de Wit, Andrea Marzi, Trenton Bushmaker, Doug Brining1, Dana Scott, Juergen A. Richt, Thomas W. Geisbert, and Heinz FeldmannComments to Author 
Author affiliations: National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA (E. de Wit, A. Marzi, T. Bushmaker, D. Brining, D. Scott, H. Feldmann); Kansas State University College of Veterinary Medicine, Manhattan, Kansas, USA (J.A. Richt); University of Texas Medical Branch, Galveston, Texas, USA (T.W. Geisbert); University of Manitoba, Winnipeg, Manitoba, Canada (H. Feldmann)

Main Article


Findings for pigs inoculated with rVSVwt and rVSV∆G/EBOVGP*

Inoculum Clinical signs VSV lesions Virus shedding from
Viremia Virus replication in tissues Seroconversion at 21 dpi
Nose Throat Rectum VSV-G EBOVGP
Mock (control) ND ND ND ND ND ND ND ND ND
rVSVwt ND 1/5† ND ND ND ND 2/5‡ 2/2 ND
rVSV∆G/EBOVGP ND ND ND 1/6§ ND ND 2/6¶ ND 3/3

*rVSVwt, recombinant wild-type vesicular stomatitis virus; rVSV∆G/EBOVGP, recombinant VSV expressing Ebola virus strain Mayinga glycoprotein; VSV-G, VSV glycoprotein; dpi, day postinoculation; ND, not detected.
†Lesion at inoculation site.
‡Snout positive in virus titration in 2 of 3 animals at 3 dpi.
§One swab collected from 1 animal positive at 3 dpi.
¶Snout positive in 1 of 3 animals at 3 dpi; inguinal lymph node positive in 1 of 3 animals at 3 dpi.

Main Article

1Current affiliation: University of Colorado, Boulder, Colorado, USA.

Page created: March 17, 2015
Page updated: March 17, 2015
Page reviewed: March 17, 2015
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