Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 5—May 2015
Research

Itaya virus, a Novel Orthobunyavirus Associated with Human Febrile Illness, Peru

Robert D. Hontz, Carolina Guevara, Eric S. Halsey, Jesus Silvas, Felix W. Santiago, Steven G. Widen, Thomas G. Wood, Wilma Casanova, Scott C. Weaver, Douglas Watts, Tadeusz J. Kochel, Hideki Ebihara, and Patricia V. AguilarComments to Author 
Author affiliations: United States Naval Medical Research Unit No. 6, Lima, Peru (R.D. Hontz, C. Guevara, E.S. Halsey, D.M. Watts, T.J. Kochel); University of Texas Medical Branch, Galveston (J. Silvas, F.W. Santiago, S.G. Widen, T.G. Wood, N. Vasilakis, P.V. Aguilar); Institute for Human Infections and Immunity, Galveston, Texas, USA (J. Silvas, F.W. Santiago, N. Vasilakis, P.V. Aguilar); Direccion Regional de Salud Loreto, Iquitos, Peru (W. Casanova); Center for Biodefense and Emerging Infectious Diseases, Galveston (N. Vasilakis, P.V. Aguilar); National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA (H. Ebihara)

Main Article

Figure 2

Neighbor-joining phylogenetic tree of group C orthobunyaviruses constructed by using MEGA5 (23) on the basis of the small (S) gene segments of published virus sequences and Itaya virus strains isolated in Peru in 1999 and 2006 (boldface). The Itaya strain segments show a close relationship to Caraparu virus. Virus strains are labeled by code designation. Numbers indicate bootstrap values for the clades to the right. Bootstrap values were obtained based on 1,000 replicates. Scale bar indicates nu

Figure 2. Neighbor-joining phylogenetic tree of group C orthobunyaviruses constructed by using MEGA5 (23) on the basis of the small gene segments of published virus sequences and Itaya virus strains isolated in Peru in 1999 and 2006 (boldface). The Itaya strain segments show a close relationship to Caraparu virus. Virus strains are labeled by code designation. Numbers indicate bootstrap values for the clades to the right. Bootstrap values were obtained based on 1,000 replicates. Scale bar indicates nucleotide substitutions per site.

Main Article

References
  1. Mohamed  M, McLees  A, Elliott  RM. Viruses in the Anopheles A, Anopheles B, and Tete serogroups in the Orthobunyavirus genus (family Bunyaviridae) do not encode an NSs protein. J Virol. 2009;83:76128. DOIPubMedGoogle Scholar
  2. Yu  XJ, Liang  MF, Zhang  SY, Liu  Y, Li  JD, Sun  YL, Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364:152332 . DOIPubMedGoogle Scholar
  3. Yanase  T, Kato  T, Aizawa  M, Shuto  Y, Shirafuji  H, Yamakawa  M, Genetic reassortment between Sathuperi and Shamonda viruses of the genus Orthobunyavirus in nature: implications for their genetic relationship to Schmallenberg virus. Arch Virol. 2012;157:16116. DOIPubMedGoogle Scholar
  4. Gerrard  SR, Li  L, Barrett  AD, Nichol  ST. Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa. J Virol. 2004;78:89226. DOIPubMedGoogle Scholar
  5. Briese  T, Calisher  CH, Higgs  S. Viruses of the family Bunyaviridae: are all available isolates reassortants? Virology. 2013;446:20716. DOIPubMedGoogle Scholar
  6. Grimstad  PR. California group virus disease. In: Monath TP, editor. The arboviruses: epidemiology and ecology. Boca Raton (FL): CRC Press; 1988. p. 99–136.
  7. Gonzales  JP, Georges  AJ. Bunyaviral fevers: Bunyamwera, Ilesha, Germiston, Bwamba and Tataguine. In: Monath TP, editor. The arboviruses: epidemiology and ecology. Boca Raton (FL): CRC Press; 1988. p. 87–98.
  8. Aguilar  PV, Barrett  AD, Saeed  MF, Watts  DM, Russell  K, Guevara  C, Iquitos virus: a novel reassortant Orthobunyavirus associated with human illness in Peru. PLoS Negl Trop Dis. 2011;5:e1315. DOIPubMedGoogle Scholar
  9. Forshey  BM, Guevara  C, Laguna-Torres  VA, Cespedes  M, Vargas  J, Gianella  A, Arboviral etiologies of acute febrile illnesses in Western South America, 2000–2007. PLoS Negl Trop Dis. 2010;4:e787. DOIPubMedGoogle Scholar
  10. Calisher  CH. Medically important arboviruses of the United States and Canada. Clin Microbiol Rev. 1994;7:89116 .PubMedGoogle Scholar
  11. Hang  J, Forshey  BM, Yang  Y, Solórzano  VF, Kuschner  RA, Halsey  ES, Genomic characterization of group C Orthobunyavirus reference strains and recent South American clinical isolates. PLoS ONE. 2014;9:e92114. DOIPubMedGoogle Scholar
  12. Aguilar  PV, Morrison  AC, Rocha  C, Watts  DM, Beingolea  L, Suarez  V, Guaroa virus infection among humans in Bolivia and Peru. Am J Trop Med Hyg. 2010;83:71421. DOIPubMedGoogle Scholar
  13. Forshey  BM, Castillo  RM, Hang  J, Group  C. Orthobunyavirus genomic sequences require validation. J Virol. 2014;88:30523. DOIPubMedGoogle Scholar
  14. de Brito Magalhães  CL, Quinan  BR, Novaes  RF, dos Santos  JR, Kroon  EG, Bonjardim  CA, Caraparu virus (group C Orthobunyavirus): sequencing and phylogenetic analysis based on the conserved region 3 of the RNA polymerase gene. Virus Genes. 2007;35:6814. DOIPubMedGoogle Scholar
  15. de Brito Magalhães  CL, Drumond  BP, Novaes  RF, Quinan  BR, de Magalhães  JC, dos Santos  JR, Identification of a phylogenetically distinct orthobunyavirus from group C. Arch Virol. 2011;156:117384. DOIPubMedGoogle Scholar
  16. Causey  OR, Causey  CE, Maroja  OM, Macedo  DG. The isolation of arthropod-borne viruses, including members of two hitherto undescribed serological groups, in the Amazon region of Brazil. Am J Trop Med Hyg. 1961;10:22749 .PubMedGoogle Scholar
  17. Srihongse  S, Galindo  P, Grayson  MA. Isolation of group C arboviruses in Panama including two new members, Patois and Zegla. Am J Trop Med Hyg. 1966;15:37984 .PubMedGoogle Scholar
  18. Pinheiro  F, Travassos da Rosa  A. Part F. Group C bunyaviral fevers. In: GM B, editor. Handbook of zoonoses. Boca Raton (FL): CRC Press; 1994. p. 212–214.
  19. Lohse  M, Bolger  AM, Nagel  A, Fernie  AR, Lunn  JE, Stitt  M, RobiNA: a user-friendly, integrated software solution for RNA-Seq-based transcriptomics. Nucleic Acids Res. 2012;40:W622–27. DOIPubMedGoogle Scholar
  20. Simpson  JT, Wong  K, Jackman  SD, Schein  JE, Jones  SJ, Birol  I. ABySS: a parallel assembler for short read sequence data. Genome Res. 2009;19:111723. DOIPubMedGoogle Scholar
  21. Langmead  B, Salzberg  SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9:3579. DOIPubMedGoogle Scholar
  22. Robinson  JT, Thorvaldsdóttir  H, Winckler  W, Guttman  M, Lander  ES, Getz  G, Integrative genomics viewer. Nat Biotechnol. 2011;29:246. DOIPubMedGoogle Scholar
  23. Tamura  K, Peterson  D, Peterson  N, Stecher  G, Nei  M, Kumar  S. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol. 2011;28:27319. DOIPubMedGoogle Scholar
  24. Travassos da Rosa  AP, Tesh  RB, Pinheiro  FP, Travassos da Rosa  JF, Peterson  NE. Characterization of eight new phlebotomus fever serogroup arboviruses (Bunyaviridae: Phlebovirus) from the Amazon region of Brazil. Am J Trop Med Hyg. 1983;32:116471 .PubMedGoogle Scholar
  25. Beaty  BJ, Calisher  CH, Shope  RE. Arboviruses. In: Schmidt NJ, Emmons, EW, editor. Diagnostic procedures for viral, rickettsial and chlamydial infections. 6th ed. Washington: American Public Health Association; 1989. p. 797–855.
  26. Aguilar  PV, Estrada-Franco  JG, Navarro-Lopez  R, Ferro  C, Haddow  AD, Weaver  SC. Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella. Future Virol. 2011;6:721–40.
  27. Epelboin  L, Boullé  C, Ouar-Epelboin  S, Hanf  M, Dussart  P, Djossou  F, Discriminating malaria from dengue fever in endemic areas: clinical and biological criteria, prognostic score and utility of the C-reactive protein: a retrospective matched-pair study in French Guiana. PLoS Negl Trop Dis. 2013;7:e2420 and. DOIPubMedGoogle Scholar
  28. Karabatsos  N, editor. International catalogue of arboviruses including certain other viruses of vertebrates. 3rd ed. San Antonio (TX): The American Society of Tropical Medicine and Hygiene for the Subcommittee on Information Exchange of the American Committee on Arthropod-borne Viruses; 1985 [cited 2015 Feb 12]. http://www.worldcat.org/title/international-catalogue-of-arboviruses-including-certain-other-viruses-of-vertebrates/oclc/13341580
  29. Calisher  CH, Gutierrez  E, Francy  DB, Alava  A, Muth  DJ, Lazuick  JS. Identification of hitherto unrecognized arboviruses from Ecuador: members of serogroups B, C, Bunyamwera, Patois, and Minatitlan. Am J Trop Med Hyg. 1983;32:87785 .PubMedGoogle Scholar
  30. Hoffmann  B, Scheuch  M, Höper  D, Jungblut  R, Holsteg  M, Schirrmeier  H. Novel orthobunyavirus in Cattle, Europe, 2011. Emerg Infect Dis. 2012;18:46972. DOIPubMedGoogle Scholar
  31. Radke  EG, Gregory  CJ, Kintziger  KW, Sauber-Schatz  EK, Hunsperger  EA, Gallagher  GR, Dengue outbreak in Key West, Florida, USA, 2009. Emerg Infect Dis. 2012;18:1357. DOIPubMedGoogle Scholar
  32. Fischer  M, Staples  JE; Arboviral Diseases Branch, National Center for Emerging and Zoonotic Infectious Diseases, CDC. Notes from the field: chikungunya virus spreads in the Americas–Caribbean and South America, 2013–2014. MMWR Morb Mortal Wkly Rep. 2014;63:5001 .PubMedGoogle Scholar
  33. McMullan  LK, Folk  SM, Kelly  AJ, MacNeil  A, Goldsmith  CS, Metcalfe  MG, A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med. 2012;367:83441. DOIPubMedGoogle Scholar
  34. Morrison  AC, Minnick  SL, Rocha  C, Forshey  BM, Stoddard  ST, Getis  A, Epidemiology of dengue virus in Iquitos, Peru 1999 to 2005: interepidemic and epidemic patterns of transmission. PLoS Negl Trop Dis. 2010;4:e670. DOIPubMedGoogle Scholar
  35. Manock  SR, Jacobsen  KH, de Bravo  NB, Russell  KL, Negrete  M, Olson  JG, Etiology of acute undifferentiated febrile illness in the Amazon basin of Ecuador. Am J Trop Med Hyg. 2009;81:14651 .PubMedGoogle Scholar
  36. Venegas  EA, Aguilar  PV, Cruz  C, Guevara  C, Kochel  TJ, Vargas  J, Ilheus virus infection in human, Bolivia. Emerg Infect Dis. 2012;18:5168.PubMedGoogle Scholar
  37. Morrison  AC, Forshey  BM, Notyce  D, Astete  H, Lopez  V, Rocha  C, Venezuelan equine encephalitis virus in iquitos, peru: urban transmission of a sylvatic strain. PLoS Negl Trop Dis. 2008;2:e349. DOIPubMedGoogle Scholar
  38. Vasconcelos  P, Travassos da Rosa  A, Pinheiro  F, Shope  R, Travassos da Rosa  J, Rodrigues  SG, Arboviruses pathogenic for man in Brazil. In: Travassos da Rosa A, Travassos da Rosa J, Vasconcelos P, editors. An overview of arbovirology in Brazil and neighboring countries. Belem (Brazil): Instituto Evandro Chagas.; 1998. P. 72–99.
  39. Nunes  MR, Travassos da Rosa  AP, Weaver  SC, Tesh  RB, Vasconcelos  PF. Molecular epidemiology of group C viruses (Bunyaviridae, Orthobunyavirus) isolated in the Americas. J Virol. 2005;79:1056170. DOIPubMedGoogle Scholar
  40. Nunes  MR, Travassos da Rosa  AP, Weaver  SC, Tesh  RB, Vasconcelos  PF. Reply to “Group C orthobunyavirus genomic sequences require validation.”. J Virol. 2014;88:3054. DOIPubMedGoogle Scholar

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
Page reviewed: April 17, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external