Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 6—June 2015
Research

Sequence Type 4821 Clonal Complex Serogroup B Neisseria meningitidis in China, 1978–2013

Bingqing Zhu, Zheng Xu, Pengcheng Du, Li Xu, Xiaofang Sun, Yuan Gao, and Zhujun ShaoComments to Author 
Author affiliations: State Key Laboratory for Infectious Disease Prevention and Control, Beijing, China (B. Zhu, Z. Xu, P. Du, Z. Shao); National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing (B. Zhu, L. Xu, X. Sun, Y. Gao, Z. Shao); Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China (Z. Shao)

Main Article

Figure 4

Analysis of the recombination events Neisseria meningitidis strains belonging to the sequence type 4821 clonal complex (strain numbers and serogroup are shown on the left). The result was from analysis using the 3seq (33) method in RDP (http://web.cbio.uct.ac.za/~darren/rdp.html). Group I and group II refer to the groups in Figure 2. Green regions represent serogroup C–specific sequences; yellow regions represent the recombination within serogroup C; gray regions represent serogroup B–specific s

Figure 4. Analysis of the recombination events Neisseria meningitidis strains belonging to the sequence type 4821 clonal complex (strain numbers and serogroup are shown on the left). The result was from analysis using the 3seq (33) method in RDP (http://web.cbio.uct.ac.za/~darren/rdp.html). Group I and group II refer to the groups in Figure 2. Green regions represent serogroup C–specific sequences; yellow regions represent the recombination within serogroup C; gray regions represent serogroup B–specific sequences; blue regions represent the recombination within serogroup B; black regions represent the recombination between serogroup B and C. Location of the polysialyltransferase gene (siaD) is shown.

Main Article

References
  1. Jafri RZ, Ali A, Messonnier NE, Tevi-Benissan C, Durrheim D, Eskola J, Global epidemiology of invasive meningococcal disease.Popul Health Metr.2013;11:17. DOIPubMedGoogle Scholar
  2. Hepkema H, Pouwels KB, van der Ende A, Westra TA, Postma MJ. Meningococcal serogroup A, C, W135 and Y conjugated vaccine: a cost-effectiveness analysis in the Netherlands.PLoS ONE.2013;8:e65036. DOIPubMedGoogle Scholar
  3. Alcalá B, Arreaza L, Salcedo C, Uria MJ, De La Fuente L, Vazquez JA. Capsule switching among C:2b:P1.2,5 meningococcal epidemic strains after mass immunization campaign, Spain.Emerg Infect Dis. 2002;8:1512–4. DOIPubMedGoogle Scholar
  4. Bilukha OO, Rosenstein N; Centers for Disease Control and Prevention. Prevention and control of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP).MMWR Recomm Rep. 2005;54:1–21.PubMedGoogle Scholar
  5. Salleras L, Dominguez A, Cardenosa N. Dramatic decline of serogroup C meningococcal disease in Catalonia (Spain) after a mass vaccination campaign with meningococcal C conjugated vaccine.Vaccine.2003;21:729–33. DOIPubMedGoogle Scholar
  6. Ramsay ME, Andrews N, Kaczmarski EB, Miller E. Efficacy of meningococcal serogroup C conjugate vaccine in teenagers and toddlers in England.Lancet.2001;357:195–6. DOIPubMedGoogle Scholar
  7. Lancellotti M, Guiyoule A, Ruckly C, Hong E, Alonso JM, Taha MK. Conserved virulence of C to B capsule switched Neisseria meningitidis clinical isolates belonging to ET-37/ST-11 clonal complex.Microbes Infect. 2006;8:191–6. DOIPubMedGoogle Scholar
  8. Castiñeiras TM, Barroso DE, Marsh JW, Tulenko MM, Krauland MG, Rebelo MC, Capsular switching in invasive Neisseria meningitidis, Brazil.Emerg Infect Dis. 2012;18:1336–8. DOIPubMedGoogle Scholar
  9. Pedro LG, Boente RF, Madureira DJ, Matos JA, Rebelo CM, Igreja RP, Diagnosis of meningococcal meningitis in Brazil by use of PCR.Scand J Infect Dis. 2007;39:28–32. DOIPubMedGoogle Scholar
  10. MacNeil JR, Medah I, Koussoube D, Novak RT, Cohn AC, Diomande FV, Neisseria meningitidis serogroup W, Burkina Faso, 2012.Emerg Infect Dis. 2014;20:394–9. DOIPubMedGoogle Scholar
  11. Pérez-Trallero E, Vicente D, Montes M, Cisterna R. Positive effect of meningococcal C vaccination on serogroup replacement in Neisseria meningitidis.Lancet.2002;360:953. DOIPubMedGoogle Scholar
  12. Swartley JS, Marfin AA, Edupuganti S, Liu LJ, Cieslak P, Perkins B, Capsule switching of Neisseria meningitidis.Pro cNatl Acad Sci U S A. 1997;94:271–6. DOIPubMedGoogle Scholar
  13. Wang Q, Shao Z, Wang X, Gao Y, Li M, Xu L, Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains.Infect Immun. 2010;78:3883–8. DOIPubMedGoogle Scholar
  14. Tsang RS, Law DK, Tyler SD, Stephens GS, Bigham M, Zollinger WD. Potential capsule switching from serogroup Y to B: the characterization of three such Neisseria meningitidis isolates causing invasive meningococcal disease in Canada.Can J Infect Dis Med Microbiol.2005;16:171–4.PubMedGoogle Scholar
  15. Beddek AJ, Li MS, Kroll JS, Jordan TW, Martin DR. Evidence for capsule switching between carried and disease-causing Neisseria meningitidis strains.Infect Immun. 2009;77:2989–94. DOIPubMedGoogle Scholar
  16. Harrison LH, Shutt KA, Schmink SE, Marsh JW, Harcourt BH, Wang X, Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era—United States, 2000–2005.J Infect Dis. 2010;201:1208–24. DOIPubMedGoogle Scholar
  17. Castilla J, Vázquez JA, Salcedo C, Garcia Cenoz M, Garcia Irure JJ, Torroba L, B:2a:p1.5 meningococcal strains likely arisen from capsular switching event still spreading in Spain.J Clin Microbiol.2009;47:463–5. DOIPubMedGoogle Scholar
  18. Stefanelli P, Fazio C, Neri A, Sofia T, Mastrantonio P. First report of capsule replacement among electrophoretic type 37 Neisseria meningitidis strains in Italy.J Clin Microbiol.2003;41:5783–6. DOIPubMedGoogle Scholar
  19. Simões MJ, Cunha M, Almeida F, Furtado C, Brum L. Molecular surveillance of Neisseria meningitidis capsular switching in Portugal, 2002–2006.Epidemiol Infect. 2009;137:161–5. DOIPubMedGoogle Scholar
  20. Parent du Chatelet I, Barboza P, Taha MK. W135 invasive meningococcal infections imported from sub-Saharan Africa to France, January to April 2012.Euro Surveill.2012;17:pii20181.PubMedGoogle Scholar
  21. Zhou H, Gao Y, Xu L, Li M, Li Q, Li Y, Distribution of serogroups and sequence types in disease-associated and carrier strains of Neisseria meningitidis isolated in China between 2003 and 2008.Epidemiol Infect. 2012;140:1296–303. DOIPubMedGoogle Scholar
  22. Hu X. Surveillance and prevention of meningococcal diseases.China Journal of Public Health.2004;20:638–40.
  23. Shao Z, Li W, Ren J, Liang X, Xu L, Diao B, Identification of a new Neisseria meningitidis serogroup C clone from Anhui Province, China.Lancet.2006;367:419–23. DOIPubMedGoogle Scholar
  24. Shao Z, Zhou H, Gao Y, Ren H, Xu L, Kan B, Neisseria meningitidis serogroup W135, China.Emerg Infect Dis. 2010;16:348–9. DOIPubMedGoogle Scholar
  25. Zhou H, Liu W, Xu L, Deng L, Deng Q, Zhuo J, Spread of Neisseria meningitidis serogroup W clone, China.Emerg Infect Dis. 2013;19:1496–9. DOIPubMedGoogle Scholar
  26. Chang Q, Tzeng YL, Stephens DS. Meningococcal disease: changes in epidemiology and prevention.Clin Epidemiol.2012;4:237–45.PubMedGoogle Scholar
  27. Yang L, Shao Z, Zhang X, Xu L, Peng J, Xu X, Genotypic characterization of Neisseria meningitidis serogroup B strains circulating in China.J Infect. 2008;56:211–8. DOIPubMedGoogle Scholar
  28. Russell JE, Jolley KA, Feavers IM, Maiden MC, Suker J. PorA variable regions of Neisseria meningitidis.Emerg Infect Dis. 2004;10:674–8. DOIPubMedGoogle Scholar
  29. Urwin R, Kaczmarski EB, Guiver M, Fox AJ, Maiden MC. Amplification of the meningococcal porB gene for non-culture serotype characterization.Epidemiol Infect. 1998;120:257–62. DOIPubMedGoogle Scholar
  30. Thompson EA, Feavers IM, Maiden MC. Antigenic diversity of meningococcal enterobactin receptor FetA, a vaccine component.Microbiology.2003;149:1849–58. DOIPubMedGoogle Scholar
  31. Delcher AL, Bratke KA, Powers EC, Salzberg SL. Identifying bacterial genes and endosymbiont DNA with Glimmer.Bioinformatics.2007;23:673–9. DOIPubMedGoogle Scholar
  32. Salminen MO, Carr JK, Burke DS, McCutchan FE. Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning.AIDS Res Hum Retroviruses. 1995;11:1423–5. DOIPubMedGoogle Scholar
  33. Boni MF, Posada D, Feldman MW. An exact nonparametric method for inferring mosaic structure in sequence triplets.Genetics.2007;176:1035–47. DOIPubMedGoogle Scholar
  34. Rishishwar L, Katz LS, Sharma NV, Rowe L, Frace M, Dolan Thomas J, Genomic basis of a polyagglutinating isolate of Neisseria meningitidis.J Bacteriol.2012;194:5649–56. DOIPubMedGoogle Scholar
  35. Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease.Vaccine.2009;27(Suppl 2):B51–63. DOIPubMedGoogle Scholar
  36. Caesar NM, Myers KA, Fan X. Neisseria meningitidis serogroup B vaccine development.MicrobPathog. 2013;57:33–40. DOIPubMedGoogle Scholar

Main Article

Page created: May 15, 2015
Page updated: May 15, 2015
Page reviewed: May 15, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external