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Volume 21, Number 6—June 2015
Letter

Fatal Bacteremia Caused by Campylobacter gracilis, United States

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To the Editor: Campylobacter species are well known to cause gastrointestinal infections in humans. However, extraintestinal illnesses caused by Campylobacter spp., including bacteremia, can also occur, primarily in immunocompromised persons (1). Campylobacter gracilis is a newly recognized species (2) that is commonly found in the oral flora and that has been associated with periodontal diseases and pleuropulmonary infections (36). Furthermore, a wide range of infectious etiologies caused by C. gracilis at different anatomic sites have been reported in the literature, suggesting its highly pathogenic potential (7,8). We describe a case of bacteremia due to C. gracilis complicated by pneumonia.

An 80-year-old man with a history of hypertension, hypertensive nephropathy, and chronic obstructive pulmonary disease (COPD) was in his usual health status when he began having worsening productive cough, fevers, and malaise; he sought health care 5 days later at Long Island College Hospital (Brooklyn, NY, USA). A heavy smoker who was noncompliant with his COPD treatment, he had frequent episodes of COPD exacerbation necessitating chronic maintenance with oral steroid therapy.

At physical examination, the patient appeared chronically ill and had mild respiratory distress. His temperature was 100.8°F, blood pressure 124/67 mm Hg, pulse 106 beats/min, respiration 22 breaths/min, and oxygen saturation 94% on room air. His heart sounds revealed tachycardia without murmurs, and his lung sounds disclosed scattered wheezing and rhonchi.

Laboratory studies revealed a leukocyte count of 14,400 cells/mm3 (reference range 4,500–11,500) with 85% polymorphonuclear leukocytes, a hemoglobin level of 11.7 g/dL (reference range 14.0–18.0), and a platelet count of 174,000/mm3 (reference range 150,000–450,000). His sodium level was 133 mmol/L (reference range 135–145), potassium 4.6 mmol/L (reference range 3.5–4.5), bicarbonate 30 mEq/L (reference range 22–28), urea nitrogen 118 mg/dL (reference range 9–23), and creatinine 5.2 mg/dL (reference range 0.7–1.3). A chest radiograph showed consolidation with large pleural effusion in the right lung.

He was empirically given vancomycin, cefepime, and azithromycin. Severe respiratory distress developed, and the patient died a few days later. Respiratory cultures at that time showed Klebsiella pneumoniae and C. gracilis. Blood cultures were positive for C. gracilis.

C. gracilis, originally known as Bacteroides gracilis, was transferred to the genus Campylobacter in 1995 after analysis of the cellular fatty acids, respiratory quinones, and proteins of B. gracilis and a comparison of them with the corresponding chemotaxonomic features of Campylobacter spp. (2). C. gracilis is a nonmotile, non–spore-forming, anaerobic gram-negative rod that uniquely requires formate and fumarate in its metabolism. C. gracilis primarily inhabits the gingival crevice and has been associated with a wide variety of periodontal diseases (3,7).

A study of 28 persons with chronic asymptomatic periradicular lesions showed C. gracilis in 6 (21.4%), including 2 (16.7%) of 12 who had acute apical periodontitis and 4 (23.5%) of 17 who had acute periradicular abscess (4). C. gracilis has also been isolated from other anatomic sites and has caused severe infections such as peritonitis, pneumonia, and bacteremia (5,8).

Our patient had C. gracilis bacteremia complicated by acute respiratory distress secondary to pneumonia. Although another gram-negative rod was isolated from the respiratory cultures, C. gracilis potentially played a major pathogenic role for this patient because of concomitant bacteremia that resulted in an unfavorable outcome. Pleuropulmonary infections with C. gracilis are not surprising because of the frequency of its detection in the human oral flora. In a study of 23 isolates of C. gracilis and their associated clinical diagnosis, 7 were from patients with lung abscess or empyema, and 2 were from those with aspiration pneumonia (6).

Campylobacter spp. are commonly associated with extraintestinal complications, including bacteremia, in immunocompromised hosts. In a study of 183 patients with Campylobacter bacteremia, the main underlying conditions were liver disease (39%) and cancer (38%). In that study, C. fetus was the most frequently identified species, found in 53% of the patients involved, followed by C. jejuni, C. coli, and C. lari (1). In another case report, C. lari bacteremia was described in a patient with multiple myeloma (9). Although uncommon, C. gracilis bacteremia has been reported in the literature (8).

Optimal antimicrobial drug treatment for C. gracilis remains to be established. Available antimicrobial susceptibility patterns in the literature have shown conflicting results (5,10). In 1 study, penicillin susceptibility was 67% and cephalosporin susceptibility was 67%–84% in 23 isolates of C. gracilis (6).

Further research is warranted to elucidate the mechanisms of pathogenicity and virulence of C. gracilis. Its pathogenic potential should not be underestimated because of the spectrum of disease, severity of infection, and its possible high frequency of antimicrobial drug resistance.

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Takashi ShinhaComments to Author 

Author affiliation: Vanderbilt University Medical Center, Nashville, Tennessee, USA

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References

  1. Pacanowski  J, Lalande V, Lacombe K, Boudraa C, Lesprit P, Legrand P, Campylobacter bacteremia: clinical features and factors associated with fatal outcome. Clin Infect Dis. 2008;47:7906. DOIPubMed
  2. Vandamme  P, Daneshvar MI, Dewhirst FE, Paster BJ, Kersters K, Goossens H, Chemotaxonomic analyses of Bacteroides gracilis and Bacteroides ureolyticus and reclassification of B. gracilis as Campylobacter gracilis comb. nov. Int J Syst Bacteriol. 1995;45:14552. DOIPubMed
  3. Tanner  A, Maiden MF, Macuch PJ, Murray LL, Kent RL Jr. Microbiota of health, gingivitis, and initial periodontitis. J Clin Periodontol. 1998;25:8598. DOIPubMed
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  6. Johnson  CC, Reinhardt JF, Edelstein MA, Mulligan ME, George WL, Finegold SM. Bacteroides gracilis, an important anaerobic bacterial pathogen. J Clin Microbiol. 1985;22:799802.PubMed
  7. Kamma  JJ, Diamanti-Kipioti A, Nakou M, Mitsis FJ. Profile of subgingival microbiota in children with primary dentition. J Periodontal Res. 2000;35:3341. DOIPubMed
  8. Molitoris  E, Wexler  HM, Finegold  SM. Sources and antimicrobial susceptibilities of Campylobacter gracilis and Sutterella wadsworthensis. Clin Infect Dis. 1997;25(Suppl 2):S2645. DOIPubMed
  9. Tauxe  RV, Patton CM, Edmonds P, Barrett TJ, Brenner DJ, Blake PA. Illness associated with Campylobacter laridis, a newly recognized Campylobacter species. J Clin Microbiol. 1985;21:2225.PubMed
  10. Baron  EJ, Ropers G, Summanen P, Courcol RJ. Bactericidal activity of selected antimicrobial agents against Bilophila wadsworthia and Bacteroides gracilis. Clin Infect Dis. 1993;16(Suppl 4):S33943. DOIPubMed

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Cite This Article

DOI: 10.3201/eid2106.142043

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Table of Contents – Volume 21, Number 6—June 2015

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Takashi Shinha, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, TVC Ste 4514, 1301 Medical Center Dr, Nashville, TN 37232, USA

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Page created: May 18, 2015
Page updated: May 18, 2015
Page reviewed: May 18, 2015
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