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Volume 21, Number 8—August 2015
Research

Response Strategies against Meningitis Epidemics after Elimination of Serogroup A Meningococci, Niger

Halima Boubacar MaïnassaraComments to Author , Juliette Paireau, Issa Idi, Jean-Paul Moulia Pelat, Odile Ouwe Missi Oukem-Boyer, Arnaud Fontanet, and Judith E. Mueller
Author affiliations: Université Pierre et Marie Curie, Paris (H.B. Maïnassara, J. Paireau); Institut Pasteur, Paris, France (H.B. Maïnassara, J. Paireau, A. Fontanet, J.E. Mueller); Centre de Recherche Médicale et Sanitaire, Niamey, Niger (H.B. Maïnassara, I. Idi, J.-P.M. Pelat, O.O.M. Oukem-Boyer); Chaire Santé et Développement, Paris (A. Fontanet); Ecole des Hautes Études en Santé Publique, Rennes, France (J.E. Mueller)

Main Article

Table 1

Comparison of estimated vaccine-preventable meningitis cases using different strategies of surveillance and meningococcal vaccine response in a situation simulating elimination of meningococcal serogroup A, Tahoua, Tillabery and Dosso regions, Niger, 2002–2012*

Strategy, surveillance–vaccination Threshold Total no. epidemic signals Population affected by signal Vaccine doses in persons 1–29 y†
 Vaccine-preventable cases‡
No.
 Per 100,000 cases
Total Median Total Median Total Median Range
Health area–health area 7 233 3,741,116 2,768,426 9,721 213 0.32 7.70 2.31 0–178.35
10 165 2,453,831 1,815,835 9,346 119 0.32 6.54 2.38 0–178.35
15 80 1,142,888 845,737 8,817 53 0.00 6.32 0.00 0–178.35
20
 49
 641,378
 474,620
 8,272
 27
 0.00
5.60
 0.00
 0–41.02
Health area–district 7 233 35,297,443 25,866,453 258,625 366 0.96 1.42 0.44 0–14.38
10 165 31,304,108 23,165,040 259,647 246 2.80 1.06 0.27 0–13.23
15 80 17,062,861 12,626,517 284,407 126 0.96 1.00 0.30 0–7.87
20
 49
 11,757,953
 8,700,885
 287,661
 58
 0.80
0.66
 0.23
 0–3.36
District–district 2 15 4,053,961 2,999,931 216,403 6 0.00 0.20 0.00 0–1.56
4 8 2,710,118 2,005,487 269,749 5 0.00 0.24 0.00 0–1.56
7 3 936,406 692,940 250,957 0 0.00 0.00 0.00 0

*Weekly incidence rate thresholds (cases/100,000 inhabitants were selected on the basis of best performance (sensitivity and specificity) to identify years of high annual incidence (531 health area years). The 3 regions had 7.5 million inhabitants.
†Case-patients <2 y of age were not excluded.
‡Median, across all health areas or districts with epidemic signal; total: for entire study area of 3 regions (population 7,648,128); mean: mean per signal (health area or district level).

Main Article

Page created: July 14, 2015
Page updated: July 14, 2015
Page reviewed: July 14, 2015
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