Volume 22, Number 1—January 2016
Human Papillomavirus Vaccination at a Time of Changing Sexual Behavior
|Probability of transmission per sexual partnership, %||80||Assumed|
|Fraction of immunity after infection clearance, %
|Rate of clearance by duration since infection, person-year||Assumed|
|New sexual partners per year, mean|
|Heterosexual population with traditional sexual behavior||2.0||Calibrated|
|Heterosexual population with gender-similar sexual behavior||1.5||Calibrated|
|Heterosexual population with gender-similar sexual behavior with increased number of partners||2.0†||SA|
|Heterosexual population with traditional sexual behavior with decreased number of partners
|Mixing between classes of sexual activity§||0.7||Calibrated|
|Duration of vaccine protection||Lifelong||Assumed|
*Values have been assumed on the basis of previous research (7). We calibrated values by fitting model-based projections to data from rural India (19) and the United States (20). SA indicates that the value was imposed on the model for univariate sensitivity analysis.
† We increased the average number of partners from 1.5, the calibrated value, to 2.0 in the population with gender-similar sexual behavior.
‡ We decreased the average number of partners from 2.0, the calibrated value, to 1.5 in the population with traditional behavior.
§”Mixing between classes of sexual activity” is a measure of the tendency for persons with similar levels of sexual activity to form sexual partnerships. It is measured on a scale where fully and randomly assortative (i.e., like-with-like) mixing corresponds to values 0 and 1, respectively. For the sensitivity analysis, we changed the value of assortative mixing by level of sexual activity from 0.7, the calibrated value, to 0.3.
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