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Volume 22, Number 10—October 2016

Vaccine-Derived Polioviruses and Children with Primary Immunodeficiency, Iran, 1995–2014

Mohammadreza Shaghaghi1, Shohreh Shahmahmoodi1, Hassan Abolhassani, Saeed Soleyman-jahi, Leila Parvaneh, Sussan Mahmoudi, Zahra Chavoshzadeh, Reza Yazdani, Seyed Mohsen Zahraei, Mohsen Ebrahimi, Mohammad H. Eslamian, Hamideh Tabatabaie, Maryam Yousefi, Yaghoob M. Kandelousi, Aliasghar Oujaghlou, Nima Rezaei, and Asghar AghamohammadiComments to Author 
Author affiliations: Tehran University of Medical Sciences, Tehran, Iran (M. Shaghaghi, S. Shahmahmoodi, H. Abolhassani, S. Soleyman-jahi, L. Parvaneh, M. Ebrahimi, M.H. Eslamian, N. Rezaei, A. Aghamohammadi); Universal Scientific Education and Research Network, Tehran (M. Shaghaghi, H. Abolhassani, S. Soleyman-jahi, R. Yazdani, N. Rezaei, A. Aghamohammadi); Research Center for Immunodeficiences, Tehran (M. Shaghaghi, H. Abolhassani, N. Rezaei, A. Aghamohammadi); Tehran University of Medical Sciences School of Public Health, Tehran (S. Shahmahmoodi, H. Tabatabaie, M. Yousefi, Y.M. Kandelousi, A. Oujaghlou); Ministry of Health and Medical Education, Tehran (S. Mahmoudi, S.M. Zahraei); Shaheed Beheshti Medical University, Tehran (Z. Chavoshzadeh); Isfahan University of Medical Sciences School of Medicine, Isfahan, Iran (R. Yazdani); Children’s Medical Center, Tehran (M. Ebrahimi, M.H. Eslamian)

Main Article

Table 1

Clinical characteristics for 14 patients infected with iVDPV, Iran, 1995–2014*

Patient no. Age, mo, at VAPP onset/sex No. doses OPV Duration, mo, from last OPV dose to VAPP onset Duration from VAPP onset to death† Site of paralysis
1 17.4/F 0 NA 8 d NA
2 7.5/M 4 1.1 4 mo Left leg, right leg, right arm, respiratory muscles
3 10.6/M 4 3.3 1 mo Left leg, right leg, right arm
4 15.1/M 4 9 11 mo Left leg, right leg
5 5.3/F 2 3.2 <1 mo Left leg, right leg
6 20.2/M 4 1.1 Alive Right leg
7 6.2/M 3 2 28 mo Right leg
8 15.7/M 4 9.2 Alive Left leg, right leg, left arm
9 25.2/M 4 6.7 <1 mo Left leg
10 6.6/M 1 6.6 2 mo Left leg, right leg
11 11.4/M 3 5.3 Alive Left leg
12 13.1/M 2 7 18 d Not available
13 10.0/M 4 3 Alive Left leg, right leg, left arm
14 9.0/M 4 2.8 Alive Left leg, right leg

*iVDPV, immunodeficiency-associated vaccine-derived poliovirus; NA, not applicable (patient 1 did not receive any OPV): OPV, oral poliovirus vaccine; VAPP, vaccine-associated paralytic poliomyelitis.
†Five patients were alive at the most recent follow-up. In March 2015, patient 6 was 9.5 years old, patient 8 was 5 years old, patient 11 was 3.5 years old, and patients 13 and 14 were 1.5 years old.

Main Article

1These authors contributed equally to this article.

Page created: September 19, 2016
Page updated: September 19, 2016
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