Viral RNA in Blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection
So Yeon Kim, Sun Jae Park, Sook Young Cho, Ran-hui Cha, Hyeon-Gun Jee, Gayeon Kim, Hyoung-Shik Shin, Yeonjae Kim, Yu Mi Jung, Jeong-Sun Yang, Sung Soon Kim, Sung Im Cho, Man Jin Kim, Jee-Soo Lee, Seung Jun Lee, Soo Hyun Seo, Sung Sup Park, and Moon-Woo Seong
Author affiliations: National Medical Center, Seoul, South Korea (S.Y. Kim, S. Park, S.Y. Cho, R. Cha, H.-G. Jee, G. Kim, H.-S. Shin, Y. Kim, Y.M. Jung); Korea Centers for Disease Control and Prevention, Cheongju-si, South Korea (J.-S. Yang, S.S. Kim); Seoul National University College of Medicine, Seoul (S.I. Cho, M.J. Kim, J.-S. Lee, S.J. Lee, S.H. Seo, S.S. Park, M.-W. Seong)
Figure. Differences in survival among Middle East respiratory syndrome coronavirus–infected patients, South Korea, 2015. A, B) Survival difference between the blood viral RNA-positive (solid line) and -negative (broken line) groups. Survival was defined as the time from initial confirmatory diagnosis to death before hospital discharge (A) (Kaplan-Meier survival analysis, log rank p = 0.009; Breslow p = 0.006) and as the time from symptom onset to death (B) (Kaplan-Meier survival analysis, log rank p = 0.017; Breslow p = 0.015). C, D) Survival difference between the high respiratory viral load (solid line) and low respiratory viral load (broken line) groups. Viral loads were classified into 2 groups: patients who harbored viral loads above the median load of patients and patients who harbored below. Survival was defined as time from initial confirmatory diagnosis to death. Cycle threshold (Ct) values were calculated for real-time reverse transcription PCRs targeting the upstream of envelope region (C) and open reading frame 1a region (D) (Kaplan-Meier survival analysis, log rank p = 0.739; Breslow p = 0.630). Tick marks along data lines indicate data-censored time points.
Page created: September 20, 2016
Page updated: September 20, 2016
Page reviewed: September 20, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.