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Volume 22, Number 10—October 2016
Letter

Polymyxin B Resistance in Carbapenem-Resistant Klebsiella pneumoniae, São Paulo, Brazil

Flávia Bartolleti, Bruna Mara Silva Seco, Carla Capuzzo dos Santos, Carolina Bragança Felipe, Mara Elisa Borsato Lemo, Tatiane da Silva Alves, Lilian F. Passadore, Marcelo J. Mimica, Suely Carlos Ferreira Sampaio, Alexandre Prehn Zavascki, and Jorge Luiz Mello SampaioComments to Author 
Author affiliations: Author affiliations: University of São Paulo School of Pharmaceutical Sciences, São Paulo, Brazil (F. Bartolleti, B.M.S. Seco, J.L. Mello Sampaio); Santa Casa de São Paulo School of Medical Sciences, São Paulo (F. Bartolleti, M.J. Mimica, S.C.F. Sampaio); Fleury Medicine and Health, São Paulo (C.C. dos Santos, C.B. Felipe, M.E.B. Lemo, T.S. Alves, J.L.M. Sampaio); University of São Paulo, São Paulo (L.F. Passadore); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (A.P. Zavascki)

Main Article

Figure

Antimicrobial resistance profile of Klebsiella pneumoniae isolated from hospital inpatients in São Paulo, Brazil. A) Carbapenem resistance trend among all K. pneumoniae isolates cultured during January 1, 2011–December 31, 2015 (n = 3,085; p<0.001). B) Polymyxin B MIC distribution stratified by carbapenem susceptibility. C) Polymyxin B resistance trend stratified by carbapenem susceptibility, 2011–2015. B, C) Carbapenem-susceptible K. pneumoniae (CSKp) isolated during January 1, 2011–June 30,

Figure. Antimicrobial resistance profile of Klebsiella pneumoniae isolated from hospital inpatients in São Paulo, Brazil. A) Carbapenem resistance trend among all K. pneumoniae isolates cultured during January 1, 2011–December 31, 2015 (n = 3,085; p<0.001). B) Polymyxin B MIC distribution stratified by carbapenem susceptibility. C) Polymyxin B resistance trend stratified by carbapenem susceptibility, 2011–2015. B, C) Carbapenem-susceptible K. pneumoniae (CSKp) isolated during January 1, 2011–June 30, 2014 (n = 1,511) and carbapenem-resistant K. pneumoniae (CRKp) isolated during January 1, 2011–December 31, 2014 (n = 436); *during July 1, 2015–December 31, 2015, only CRKp were tested for polymyxin B susceptibility (n = 377). All statistical analyses were conducted using SAS Studio 3.4 (SAS Institute, Inc., Cary, NC, USA). The statistical significance of a trend in resistance rates was evaluated using the χ2 test, in which p values <0.05 were considered significant: K. pneumoniae, p<0.001; CSKp, p = 0.004; CRKp, p = 0.003.

Main Article

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Page updated: September 20, 2016
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