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Volume 22, Number 11—November 2016
Dispatch

Severe Fever with Thrombocytopenia Syndrome in Patients Suspected of Having Scrub Typhus

Yu Mi Wi, Hye In Woo, Dahee Park, Keun Hwa LeeComments to Author , Cheol-In Kang, Doo Ryeon Chung, Kyong Ran PeckComments to Author , and Jae-Hoon Song
Author affiliations: Sungkyunkwan University, Changwon-si, South Korea (Y.M. Wi, H.I. Woo); Jeju National University School of Medicine, Jeju-si, South Korea (D. Park, K.H. Lee); Sungkyunkwan University School of Medicine, Seoul, South Korea (C-.I. Kang, D.R Chung, K.R. Peck, J.-H. Song)

Main Article

Table

Demographic and laboratory characteristics of SFTS patients, South Korea, 2013*

Characteristics SFTS PCR+, n = 17 SFTS PCR–, n = 57 p value
Male sex, no (%)
7 (41.2)
24 (42.1)
0.946
Age, mean ± SD 64.2 ± 15.5 54.5 ± 16.4 0.033
Farming, no (%)
12 (70.6)
29 (50.9)
0.151
Coexisting condition, no. (%)



Chronic lung disease†
3 (17.6)
3 (5.3)
0.130
Chronic heart disease‡
6 (35.3)
11 (19.3)
0.197
Chronic renal disease
1 (5.9)
1 (1.8)
0.409
Diabetes
4 (23.5)
5 (8.8)
0.197
Chronic liver disease
1 (5.9)
5 (8.8)
0.580
Corticosteroid use
0
2 (3.5)
0.591
Cancer
0
3 (5.3)
0.451
Cerebrovascular disease
1 (5.9)
3 (5.3)
0.657
Clinical presentation



Fever (temperature >38.3°C)
13 (76.5)
48 (84.2)
0.480
Headache
5 (29.4)
18 (31.6)
0.865
Myalgia
8 (47.1)
31 (54.4)
0.595
Anorexia
10 (58.8)
5 (8.8)
<0.001
Nausea/vomiting
8 (47.1)
10 (17.5)
0.022
Abdominal pain
2 (11.8)
5 (8.8)
0.657
Diarrhea
1 (5.9)
1 (1.8)
0.409
Cough
1 (5.9)
5 (8.8)
0.580
Dyspnea
1 (5.9)
2 (3.5)
0.549
Decreased consciousness
3 (17.6)
-
0.010
Rash
12 (70.6)
34 (59.6)
0.414
Laboratory findings at admission



Leukopenia (<4,000 cells/mm3) no. (%)
2 (11.8)
18 (31.6)
0.131
Lymphocytopenia (<1,500 cells/mm3) no. (%)
6 (35.5)
43 (75.4)
0.002
Anemia (hematocrit <30%), no. (%)
3 (17.6)
4 (7.0)
0.341
Thrombocytopenia (<106cells/mm3) no. (%)
7 (41.2)
13 (22.8)
0.221
CPK, IU/L, median (IQR)
67 (33–132)
76 (45–128)
0.512
LDH, IU/L, mean ± SD
533 ± 202
402 ± 151
0.021
AST, IU/L, median (IQR)
104 (48–194)
69 (54–112)
0.210
ALT, IU/L, median (IQR)
70 (30–119)
53 (35–83)
0.616
PT (INR), median (IQR)
1.08 (1.03–1.15)
1.03 (0.97–1.09)
0.057
CRP, mg/L, median (IQR)
71.6 (46.4–110.4)
42.9 (23.2–80.3)
0.034
BUN, mg/dL, median (IQR)
12.7 (9.3–18.2)
12.7 (9.4–15.3)
0.634
Creatinine, mg/dL, median (IQR)
0.9 (0.8–1.3)
0.8 (0.6–1.0)
0.510
Albumin, g/dL, mean ± SD
2.9 ± 0.7
3.3 ± 0.5
0.005
Hematuria, no. (%)
3 (20.0)
20 (35.7)
0.356
Outcome



Intensive respiratory or vasopressor support
3 (17.6)
1 (1.8)
0.036
Time from symptom onset to admission, d, median (IQR)
3 (3–6.5)
4 (3–6)
0.599
Hospital stay, d, median (IQR) 0 (0–3) 1 (0–4) 0.432
Death, no (%) 1 (5.9) 0 0.230

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CPK, creatinine phosphokinase; CRP, C-reactive protein; INR, international normalized ratio; IQR, interquartile range; LDH, lactate dehydrogenase; PT, prothrombin time; SFTS, severe fever with thrombocytopenia syndrome.
†Asthma, chronic obstructive pulmonary disease, bronchiectasis.
‡Underlying coronary heart disease, chronic heart failure.

Main Article

Page created: October 19, 2016
Page updated: October 19, 2016
Page reviewed: October 19, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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