Volume 22, Number 11—November 2016
Dispatch
Severe Fever with Thrombocytopenia Syndrome in Patients Suspected of Having Scrub Typhus
Yu Mi Wi, Hye In Woo, Dahee Park, Keun Hwa Lee
, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck , and Jae-Hoon Song
, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck , and Jae-Hoon Song
Table
Demographic and laboratory characteristics of SFTS patients, South Korea, 2013*
| Characteristics | SFTS PCR+, n = 17 | SFTS PCR–, n = 57 | p value |
|---|---|---|---|
| Male sex, no (%) |
7 (41.2) |
24 (42.1) |
0.946 |
| Age, mean ± SD | 64.2 ± 15.5 | 54.5 ± 16.4 | 0.033 |
| Farming, no (%) |
12 (70.6) |
29 (50.9) |
0.151 |
| Coexisting condition, no. (%) |
|||
| Chronic lung disease† |
3 (17.6) |
3 (5.3) |
0.130 |
| Chronic heart disease‡ |
6 (35.3) |
11 (19.3) |
0.197 |
| Chronic renal disease |
1 (5.9) |
1 (1.8) |
0.409 |
| Diabetes |
4 (23.5) |
5 (8.8) |
0.197 |
| Chronic liver disease |
1 (5.9) |
5 (8.8) |
0.580 |
| Corticosteroid use |
0 |
2 (3.5) |
0.591 |
| Cancer |
0 |
3 (5.3) |
0.451 |
| Cerebrovascular disease |
1 (5.9) |
3 (5.3) |
0.657 |
| Clinical presentation |
|||
| Fever (temperature >38.3°C) |
13 (76.5) |
48 (84.2) |
0.480 |
| Headache |
5 (29.4) |
18 (31.6) |
0.865 |
| Myalgia |
8 (47.1) |
31 (54.4) |
0.595 |
| Anorexia |
10 (58.8) |
5 (8.8) |
<0.001 |
| Nausea/vomiting |
8 (47.1) |
10 (17.5) |
0.022 |
| Abdominal pain |
2 (11.8) |
5 (8.8) |
0.657 |
| Diarrhea |
1 (5.9) |
1 (1.8) |
0.409 |
| Cough |
1 (5.9) |
5 (8.8) |
0.580 |
| Dyspnea |
1 (5.9) |
2 (3.5) |
0.549 |
| Decreased consciousness |
3 (17.6) |
- |
0.010 |
| Rash |
12 (70.6) |
34 (59.6) |
0.414 |
| Laboratory findings at admission |
|||
| Leukopenia (<4,000 cells/mm3) no. (%) |
2 (11.8) |
18 (31.6) |
0.131 |
| Lymphocytopenia (<1,500 cells/mm3) no. (%) |
6 (35.5) |
43 (75.4) |
0.002 |
| Anemia (hematocrit <30%), no. (%) |
3 (17.6) |
4 (7.0) |
0.341 |
| Thrombocytopenia (<106cells/mm3) no. (%) |
7 (41.2) |
13 (22.8) |
0.221 |
| CPK, IU/L, median (IQR) |
67 (33–132) |
76 (45–128) |
0.512 |
| LDH, IU/L, mean ± SD |
533 ± 202 |
402 ± 151 |
0.021 |
| AST, IU/L, median (IQR) |
104 (48–194) |
69 (54–112) |
0.210 |
| ALT, IU/L, median (IQR) |
70 (30–119) |
53 (35–83) |
0.616 |
| PT (INR), median (IQR) |
1.08 (1.03–1.15) |
1.03 (0.97–1.09) |
0.057 |
| CRP, mg/L, median (IQR) |
71.6 (46.4–110.4) |
42.9 (23.2–80.3) |
0.034 |
| BUN, mg/dL, median (IQR) |
12.7 (9.3–18.2) |
12.7 (9.4–15.3) |
0.634 |
| Creatinine, mg/dL, median (IQR) |
0.9 (0.8–1.3) |
0.8 (0.6–1.0) |
0.510 |
| Albumin, g/dL, mean ± SD |
2.9 ± 0.7 |
3.3 ± 0.5 |
0.005 |
| Hematuria, no. (%) |
3 (20.0) |
20 (35.7) |
0.356 |
| Outcome |
|||
| Intensive respiratory or vasopressor support |
3 (17.6) |
1 (1.8) |
0.036 |
| Time from symptom onset to admission, d, median (IQR) |
3 (3–6.5) |
4 (3–6) |
0.599 |
| Hospital stay, d, median (IQR) | 0 (0–3) | 1 (0–4) | 0.432 |
| Death, no (%) | 1 (5.9) | 0 | 0.230 |
*ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CPK, creatinine phosphokinase; CRP, C-reactive protein; INR, international normalized ratio; IQR, interquartile range; LDH, lactate dehydrogenase; PT, prothrombin time; SFTS, severe fever with thrombocytopenia syndrome.
†Asthma, chronic obstructive pulmonary disease, bronchiectasis.
‡Underlying coronary heart disease, chronic heart failure.
Page created: October 19, 2016
Page updated: October 19, 2016
Page reviewed: October 19, 2016
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