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Volume 22, Number 3—March 2016
Research

Underestimation of Invasive Meningococcal Disease in Italy

Chiara Azzari1Comments to Author , Francesco Nieddu1, Maria Moriondo1, Giuseppe Indolfi, Clementina Canessa, Silvia Ricci, Leila Bianchi, Daniele Serranti, Giovanni Maria Poggi, and Massimo Resti
Author affiliations: Anna Meyer Children’s University Hospital, Florence (C. Azzari, F. Nieddu, M. Moriondo, G. Indolfi, C. Canessa, S. Ricci, L. Bianchi, D. Serranti, G.M. Poggi, M. Resti); University of Florence Department of Health Sciences, Florence, Italy (C. Azzari, F. Nieddu, M. Moriondo, S. Ricci, D. Serranti, G.M. Poggi)

Main Article

Table 3

Distribution of rPCR and culture-based test results for Neisseria meningitidis for CSF and blood samples from a national register for molecular surveillance of invasive bacterial disease, Italy, 2007–2014*

Type of sample No. samples/no. tested (%)
Positive by rPCR Negative by rPCR Not tested by rPCR Total†
CSF
Culture positive 33 0 0 33/90 (36.7)
Culture negative 55 2 0 57/90 (63.3)
Not tested with culture 72 0 0 0
Total
 160/162 (98.8)
 2/162 (1.2)
 0
 0
Blood
Culture positive 16 0 10 26/107 (24.3)
Culture negative 37 10 34 81/107 (75.7)
Not tested with culture 51 2 0 0
Total
 104/116 (89.7)
 12/116 (10.3)
 0
 0
Total, CSF or blood
Culture positive 49 0 10 59/197 (29.9)
Culture negative 92 12 34 138/197 (70.1)
Not tested with culture 123 2 0 0
Total 264/278 (95.0) 14/278 (5.0) 0 0

*A total of 162 CSF samples were tested with rPCR, and 90 were tested with culture-based methods. A total of 116 blood samples were tested with rPCR, and 107 were tested with culture-based methods. CSF, cerebrospinal fluid; rPCR, real-time PCR.
†Proportion of samples that were positive, negative, or not tested with culture-based methods.

Main Article

1These authors contributed equally to this article.

Page created: February 18, 2016
Page updated: February 18, 2016
Page reviewed: February 18, 2016
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