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Volume 22, Number 5—May 2016
Research

Astrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection

Samuel Cordey1, Diem-Lan Vu1Comments to Author , Manuel Schibler, Arnaud G. L’Huillier, Francisco Brito, Mylène Docquier, Klara M. Posfay-Barbe, Thomas J. Petty, Lara Turin, Evgeny M. Zdobnov, and Laurent Kaiser
Author affiliations: University of Geneva Hospitals, Geneva, Switzerland (S. Cordey, D.-L. Vu, M. Schibler, A.G. L’Huillier, K.M. Posfay-Barbe, L. Turin, L. Kaiser); Geneva University Medical School, Geneva (S. Cordey, D.-L. Vu, M. Schibler, F. Brito, M. Docquier, K.M. Posfay-Barbe, T.J. Petty, L. Turin, E.M. Zdobnov, L. Kaiser); Swiss Institute of Bioinformatics, Geneva (F. Brito, T.J. Petty, E.M. Zdobnov)

Main Article

Table

Clinical cases of astrovirus infection recovered outside the digestive tract in humans by next-generation sequencing or real-time RT-PCR*

Authors (reference or figure)
 Astrovirus strain
 Species
 Sample analyzed and results
Brain biopsy/CSF
 Plasma/
serum
 Feces
 Urine
 NPS
 Other
Holtz et al. (11) HAstV MLB2 MAstV 6 NP + NP NP + NP
This study HAstV MLB2 MAstV 6
Case-patient (Figure 2, panels A, B) + + + + – NP
HSCT recipient (Figure 2, panel C) + + + NP NP NP
Patient D (Figure 2, panel D)
NP
 +
 +
 NP
 NP
 NP
Wunderli et al. (12) Classical HAstV serotype 4 MAstV1
Patient 1 –/NP + + –/NP + -/NP
Patient 2 + + + –/NP –/NP +†
Patient 3
+
 –/NP
 –/NP
 –/NP
 +
 –/NP
Quan et al. (13)
 HAstV-PS
 MAstV 9
 +
 NP
 NP
 NP
 NP
 –‡
Brown et al. (14)
 HAstV-VA1/HMO-C-UK1
 MAstV 9
 +
 +
 +
 NP
 NP
 NP
Naccache et al. (15)
 HAstV-VA1/HMO-C-UK1
 MAstV 9
 +
 NP
 NP
 NP
 NP
 NP
Fremond et al. (16) HAstV-VA1/HMO-C-PA MAstV 9 + NP NP NP NP NP

*RT-PCR, reverse transcription PCR; CSF, cerebrospinal fluid; NPS, nasopharyngeal swab; HAstV, human astrovirus; MAstV, mamastrovirus; NP; not performed; +, positive; –, negative; HSCT, human stem cell transplant.
†Vesicle swab, heart, lung, spleen, bone marrow, kidney, small intestine.
‡Kidney, liver, spleen.

Main Article

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Main Article

1These first authors contributed equally to this article.

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Page updated: April 13, 2016
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