Volume 22, Number 5—May 2016
Research
Astrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection
Table
Clinical cases of astrovirus infection recovered outside the digestive tract in humans by next-generation sequencing or real-time RT-PCR*
Authors (reference or figure) |
Astrovirus strain |
Species |
Sample analyzed and results | |||||
---|---|---|---|---|---|---|---|---|
Brain biopsy/CSF |
Plasma/
serum |
Feces |
Urine |
NPS |
Other |
|||
Holtz et al. (11) | HAstV MLB2 | MAstV 6 | NP | + | NP | NP | + | NP |
This study | HAstV MLB2 | MAstV 6 | ||||||
Case-patient (Figure 2, panels A, B) | + | + | + | + | – | NP | ||
HSCT recipient (Figure 2, panel C) | + | + | + | NP | NP | NP | ||
Patient D (Figure 2, panel D) |
NP |
+ |
+ |
NP |
NP |
NP |
||
Wunderli et al. (12) | Classical HAstV serotype 4 | MAstV1 | ||||||
Patient 1 | –/NP | + | + | –/NP | + | -/NP | ||
Patient 2 | + | + | + | –/NP | –/NP | +† | ||
Patient 3 |
+ |
–/NP |
–/NP |
–/NP |
+ |
–/NP |
||
Quan et al. (13) |
HAstV-PS |
MAstV 9 |
+ |
NP |
NP |
NP |
NP |
–‡ |
Brown et al. (14) |
HAstV-VA1/HMO-C-UK1 |
MAstV 9 |
+ |
+ |
+ |
NP |
NP |
NP |
Naccache et al. (15) |
HAstV-VA1/HMO-C-UK1 |
MAstV 9 |
+ |
NP |
NP |
NP |
NP |
NP |
Fremond et al. (16) | HAstV-VA1/HMO-C-PA | MAstV 9 | + | NP | NP | NP | NP | NP |
*RT-PCR, reverse transcription PCR; CSF, cerebrospinal fluid; NPS, nasopharyngeal swab; HAstV, human astrovirus; MAstV, mamastrovirus; NP; not performed; +, positive; –, negative; HSCT, human stem cell transplant.
†Vesicle swab, heart, lung, spleen, bone marrow, kidney, small intestine.
‡Kidney, liver, spleen.
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1These first authors contributed equally to this article.
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