Volume 22, Number 5—May 2016
Letter
Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia
Table
Clinical laboratory results for 15-year-old girl with sickle cell disease who died of Zika virus infection, Colombia*
| Laboratory test | Baseline value | Value at hospitalization (Malambo) | Value 24 h later (ICU, Barranquilla) |
|---|---|---|---|
| Leukocyte count, × 109 cells/L | 10.00 | 8.23 | ND |
| Hemoglobin level, g/dL | 7.00 | 8.10 | 4.20 |
| Hematocrit, % | 28.00 | 25.00 | 13.00 |
| MCV, fL/erythrocyte | 73.00 | 73.00 | ND |
| Reticulocytes, % | 1.00 | 1.00 | ND |
| Total bilirubin, mg/dL | ND | 2.97 | ND |
| Direct bilirubin, mg/dL | ND | 1.67 | ND |
| Platelet count/mL |
ND |
54,000.00 |
76,000.00 |
| PT, s | ND | ND | 33.3 (control 13.10) |
| aPTT, s | ND | ND | 45.0 (control 29.80) |
| ALT, mg/dL | ND | ND | 2,245.00 |
| AST, mg/dL | ND | ND | 3,215.00 |
| LDH , IU/L |
ND |
ND |
441.00 |
| Alkaline hemoglobin electrophoresis, % | |||
| HbS | ND | ND | 62.50 |
| HbC–E | ND | ND | 37.50 |
| HbF |
ND |
ND |
0.00 |
| Malaria thick and thin blood smears† | Not done | Not done | – |
| HIV-1 and HIV-2 ELISA† | Not done | Not done | – |
| MAT for Leptospira spp.† |
Not done |
Not done |
– |
| RT-PCR for DENV† | Not done | Not done | – |
| RT-PCR for CHIKV† | Not done | Not done | – |
| RT-PCR for YFV† | Not done | Not done | – |
| RT-PCR for ZIKV† | Not done | Not done | + |
*ICU, intensive care unit; ND, not determined; MCV, mean corpuscular volume; PT, prothrombin time; aPTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; Hb, hemoglobin; –, negative; MAT; microscopic agglutination test; RT-PCR, reverse transcription PCR; DENV, dengue virus; CHIKV, chikungunya virus; YFV, yellow fever virus; ZIKV, Zika virus; +, positive.
†Blood samples were obtained 5 days after illness onset. These tests were performed at the National Reference Laboratory of the National Institute of Health, Bogotá, Colombia.
Page created: April 14, 2016
Page updated: April 14, 2016
Page reviewed: April 14, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.