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Volume 22, Number 5—May 2016

Fatal Sickle Cell Disease and Zika Virus Infection in Girl from Colombia

Laura Arzuza-Ortega, Arnulfo Polo, Giamina Pérez-Tatis, Humberto López-García, Edgar Parra, Lissethe C. Pardo-Herrera, Angélica M. Rico-Turca, Wilmer Villamil-Gómez, and Alfonso J. Rodríguez-Morales
Author affiliations: Entidades Promotoras de Salud Barrios Unido Mutual, Quibdó, Colombia (L. Arzuza-Ortega); Empresa Social del Estado Hospital de Malambo, Malambo, Colombia (A. Polo); Hospital Metropolitano, Barranquilla, Colombia (G. Pérez-Tatis, H. López-García); Instituto Nacional de Salud, Bogotá, Colombia (E. Parra, L.C. Pardo-Herrera, A.M. Rico-Turca); Hospital Universitario de Sincelejo, Sincelejo, Colombia, (W. Villamil-Gómez); Universidad del Atlántico, Barranquilla (W. Villamil-Gómez); Universidad de Cartagena, Cartagena, Colombia (W. Villamil-Gómez); Universidad Tecnológica de Pereira, Pereira, Colombia (A.J. Rodriguez-Morales)

Main Article


Clinical laboratory results for 15-year-old girl with sickle cell disease who died of Zika virus infection, Colombia*

Laboratory test Baseline value Value at hospitalization (Malambo) Value 24 h later (ICU, Barranquilla)
Leukocyte count, × 109 cells/L 10.00 8.23 ND
Hemoglobin level, g/dL 7.00 8.10 4.20
Hematocrit, % 28.00 25.00 13.00
MCV, fL/erythrocyte 73.00 73.00 ND
Reticulocytes, % 1.00 1.00 ND
Total bilirubin, mg/dL ND 2.97 ND
Direct bilirubin, mg/dL ND 1.67 ND
Platelet count/mL
PT, s ND ND 33.3 (control 13.10)
aPTT, s ND ND 45.0 (control 29.80)
ALT, mg/dL ND ND 2,245.00
AST, mg/dL ND ND 3,215.00
Alkaline hemoglobin electrophoresis, %
HbS ND ND 62.50
HbC–E ND ND 37.50
Malaria thick and thin blood smears† Not done Not done
HIV-1 and HIV-2 ELISA† Not done Not done
MAT for Leptospira spp.†
Not done
Not done

RT-PCR for DENV† Not done Not done
RT-PCR for CHIKV† Not done Not done
RT-PCR for YFV† Not done Not done
RT-PCR for ZIKV† Not done Not done +

*ICU, intensive care unit; ND, not determined; MCV, mean corpuscular volume; PT, prothrombin time; aPTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; Hb, hemoglobin; –, negative; MAT; microscopic agglutination test; RT-PCR, reverse transcription PCR; DENV, dengue virus; CHIKV, chikungunya virus; YFV, yellow fever virus; ZIKV, Zika virus; +, positive.
†Blood samples were obtained 5 days after illness onset. These tests were performed at the National Reference Laboratory of the National Institute of Health, Bogotá, Colombia.

Main Article

Page created: April 14, 2016
Page updated: April 14, 2016
Page reviewed: April 14, 2016
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