Volume 22, Number 6—June 2016
Dispatch
Shigella Antimicrobial Drug Resistance Mechanisms, 2004–2014
Magdalena Nüesch-Inderbinen, Nicole Heini, Katrin Zurfluh, Denise Althaus, Herbert Hächler, and Roger Stephan
Table 1
Antimicrobial drug resistance of 344 Shigella spp. isolates, Switzerland, 2004–2014
| Agent | No. (%) isolates |
|||
|---|---|---|---|---|
| S. sonnei, n = 179 | S. flexneri, n = 107 | S. dysenteriae, n = 33 | S. boydii, n = 25 | |
| Ampicllin | 31 17.3) | 73 (68.2) | 19 (57.6) | 12 (48) |
| Amoxicillin/clavulanic acid | 2 (1.1) | 1 (0.9) | 0 | 0 (0) |
| Cephalothin | 12 (6.7) | 0 | 0 | 0 |
| Cefotaxime | 8 (4.5) | 0 | 0 | 0 |
| Nalidixic acid | 49 (27.4) | 15 (14) | 2 (6) | 2 (8) |
| Ciprofloxacin | 27 (15) | 9 (8.4) | 0 | 0 |
| Azithromycin* | 2 (1.1) | 5 (4.7) | 0 | 0 |
| Trimethoprim | 172 (96) | 70 (65.4) | 20 (60.6) | 15 (60) |
| Sulfamethoxazole | 151 (84.4) | 71 (66.4) | 19 (57.6) | 16 (64) |
| Kanamycin | 1 (0.5) | 1 (0.9) | 0 | 0 |
| Gentamicin | 4 (2.2) | 0 | 0 | 0 |
| Streptomycin | 163 (91) | 81 (75.7) | 24 (72.7) | 18 (72) |
| Tetracycline | 145 (81) | 83 (77.6) | 22 (66.6) | 13 (52) |
| Chloramphenicol | 6 (3.4) | 56 (52.3) | 9 (27.3) | 2 (8) |
*For azithromycin, no Clinical and Laboratory Standards Institute breakpoints for Enterobacteriaceae exist. Isolates harboring mph(A) were regarded as resistant.
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