Table 2

Shigella Antimicrobial Drug Resistance Mechanisms, 2004–2014

Magdalena Nüesch-Inderbinen, Nicole Heini, Katrin Zurfluh, Denise Althaus, Herbert Hächler, and Roger Stephan

Author affiliations: University of Zurich, Zurich, Switzerland

Presence of PMQR determinants, amino acid changes in QRDR, ESBLs and the macrolide resistance gene mph(A) in Shigella spp. isolated in Switzerland, 2004–2014, and MICs of azithromycin against isolates containing mph(A)*

Year of isolation, strain	Shigella species	PMQR	QRDR				ESBL	mph(A)	MIC, μg/mL
			GyrA		ParC
			Ser83	Asp87	Ser80	Ala85
2004
412–04	sonnei	–	Leu	wt	wt	wt	ND	–	ND
1497–04	flexneri	–	ND	ND	ND	ND	ND	+	24
2005
1826–05	sonnei	–	Leu	wt	wt	wt	ND	–	ND
263–05	flexneri	–	Leu	wt	wt	wt	ND	–	ND
693–05	flexneri	–	ND	ND	ND	ND	ND	+	32
1319–05	sonnei	–	ND	ND	ND	ND	ND	+	256
1742–05	flexneri	–	ND	ND	ND	ND	ND	+	12
2006
1920–06	flexneri	–	Leu	wt	wt	wt	ND	–	ND
1549–06	sonnei	–	Leu	wt	wt	wt	ND	–	ND
2007
2389–07	sonnei	–	Leu	wt	wt	wt	ND	–	ND
1374–07	flexneri	–	Leu	wt	wt	wt	ND	–	ND
2008
2372–08	boydii	–	Leu	wt	wt	wt	ND	–	ND
2157–08	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
2134–08	boydii	–	Leu	wt	wt	Ser	ND	–	ND
822–08	flexneri	–	Leu	Gly	Ile	wt	ND	–	ND
959–08	boydii	qnrS1	ND	ND	ND	ND	ND	–	ND
2009
09–2751	flexneri	–	Leu	wt	wt	wt	ND	–	ND
09–2192	sonnei	–	Leu	wt	wt	wt	CTX-M-14	–	ND
09–1001	dysenteriae	–	wt	Asn	wt	wt	ND	–	ND
09–684	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
006–09	flexneri	–	Leu	Asn	Ile	wt	ND	–	ND
375–09	flexneri	qnrS1	ND	ND	ND	ND	ND	–	ND
09–736	sonnei	–	ND	ND	ND	ND	CTX-M-15	–	ND
2010
10–1982	sonnei	–	wt	Tyr	wt	wt	ND	–	ND
10–1935	boydii	–	Leu	wt	wt	wt	ND	–	ND
10–1557	dysenteriae	–	Leu	wt	wt	wt	ND	–	ND
10–433	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
10–383	flexneri	–	Leu	wt	wt	wt	ND	–	ND
10–1166	flexneri	qnrS1	ND	ND	ND	ND	ND	–	ND
10–929	boydii	qnrS1	ND	ND	ND	ND	ND	–	ND
10–338	dysenteriae	qnrS1	ND	ND	ND	ND	ND	–	ND
2011
11–0683	sonnei	–	wt	Tyr	wt	wt	CTX-M-15	–	ND
11–0616	flexneri	–	wt	Tyr	wt	wt	ND	–	ND
11–0162	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
11–0029	flexneri	–	Leu	Gly	Ile	wt	ND	–	ND
11–1023	sonnei	–	ND	ND	ND	ND	CTX-M-15	–	ND
2012
12–0580	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
12–0273	flexneri	–	Leu	Gly	Ile	wt	ND	–	ND
12–0094	dysenteriae	–	Leu	wt	wt	wt	ND	–	ND
12–0573	dysenteriae	qnrS1	ND	ND	ND	ND	ND	–	ND
12–0087	flexneri	qnrS1	ND	ND	ND	ND	ND	–	ND
2013
13–2304	flexneri	–	Leu	Gly	Ile	wt	ND	–	ND
13–1996	boydii	–	Leu	wt	wt	Ser	ND	–	ND
13–1909	sonnei	–	wt	Tyr	wt	wt	CTX-M-14	–	ND
13–0136	flexneri	qnrS1	ND	ND	ND	ND	ND	–	ND
13–1494	dysenteriae	qnrS1	ND	ND	ND	ND	ND	–	ND
13–1295	sonnei	qnrS1	ND	ND	ND	ND	ND	–	ND
13–1205	boydii	qnrS1	ND	ND	ND	ND	ND	–	ND
13–2356	boydii	qnrS1	ND	ND	ND	ND	ND	–	ND
2014
14–2394	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
14–0754	flexneri	–	Leu	Asn	Ile	wt	ND	+	16
14–0369	sonnei	–	Leu	Gly	Ile	wt	ND	–	ND
14–1127	sonnei	–	ND	ND	ND	ND	CTX-M-15	–	ND
14–1843	flexneri	–	ND	ND	ND	ND	ND	+	48
14–1990	sonnei	qnrB4, qepA	ND	ND	ND	ND	ND	+	>256
14–1929	sonnei	qnrB19	ND	ND	ND	ND	ND	–	ND
14–1570	dysenteriae	qnrS1	ND	ND	ND	ND	ND	–	ND
14–1495	sonnei	–	ND	ND	ND	ND	CTX-M-3	–	ND
14–1820	sonnei	–	ND	ND	ND	ND	CTX-M-15	–	ND

*ESBL, extended-spectrum β-lactamase; ND, not determined; PMQR, plasmid-mediated quinolone resistance; QRDR, quinolone resistance determining regions; wt, wild type; –, negative; +, positive.

Main Article

Page created: May 16, 2016

Page updated: May 16, 2016

Page reviewed: May 16, 2016

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Volume 22, Number 6—June 2016

Dispatch

Shigella Antimicrobial Drug Resistance Mechanisms, 2004–2014

Table 2