Volume 22, Number 6—June 2016
Dispatch
Shigella Antimicrobial Drug Resistance Mechanisms, 2004–2014
Table 2
Presence of PMQR determinants, amino acid changes in QRDR, ESBLs and the macrolide resistance gene mph(A) in Shigella spp. isolated in Switzerland, 2004–2014, and MICs of azithromycin against isolates containing mph(A)*
Year of isolation, strain | Shigella species | PMQR | QRDR |
ESBL | mph(A) | MIC, μg/mL | ||||
---|---|---|---|---|---|---|---|---|---|---|
GyrA |
ParC |
|||||||||
Ser83 | Asp87 | Ser80 | Ala85 | |||||||
2004 | ||||||||||
412–04 | sonnei | – | Leu | wt | wt | wt | ND | – | ND | |
1497–04 |
flexneri |
– |
ND |
ND |
ND |
ND |
ND |
+ |
24 |
|
2005 | ||||||||||
1826–05 | sonnei | – | Leu | wt | wt | wt | ND | – | ND | |
263–05 | flexneri | – | Leu | wt | wt | wt | ND | – | ND | |
693–05 | flexneri | – | ND | ND | ND | ND | ND | + | 32 | |
1319–05 | sonnei | – | ND | ND | ND | ND | ND | + | 256 | |
1742–05 |
flexneri |
– |
ND |
ND |
ND |
ND |
ND |
+ |
12 |
|
2006 | ||||||||||
1920–06 | flexneri | – | Leu | wt | wt | wt | ND | – | ND | |
1549–06 |
sonnei |
– |
Leu |
wt |
wt |
wt |
ND |
– |
ND |
|
2007 | ||||||||||
2389–07 | sonnei | – | Leu | wt | wt | wt | ND | – | ND | |
1374–07 |
flexneri |
– |
Leu |
wt |
wt |
wt |
ND |
– |
ND |
|
2008 | ||||||||||
2372–08 | boydii | – | Leu | wt | wt | wt | ND | – | ND | |
2157–08 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
2134–08 | boydii | – | Leu | wt | wt | Ser | ND | – | ND | |
822–08 | flexneri | – | Leu | Gly | Ile | wt | ND | – | ND | |
959–08 |
boydii |
qnrS1 |
ND |
ND |
ND |
ND |
ND |
– |
ND |
|
2009 | ||||||||||
09–2751 | flexneri | – | Leu | wt | wt | wt | ND | – | ND | |
09–2192 | sonnei | – | Leu | wt | wt | wt | CTX-M-14 | – | ND | |
09–1001 | dysenteriae | – | wt | Asn | wt | wt | ND | – | ND | |
09–684 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
006–09 | flexneri | – | Leu | Asn | Ile | wt | ND | – | ND | |
375–09 | flexneri | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
09–736 |
sonnei |
– |
ND |
ND |
ND |
ND |
CTX-M-15 |
– |
ND |
|
2010 | ||||||||||
10–1982 | sonnei | – | wt | Tyr | wt | wt | ND | – | ND | |
10–1935 | boydii | – | Leu | wt | wt | wt | ND | – | ND | |
10–1557 | dysenteriae | – | Leu | wt | wt | wt | ND | – | ND | |
10–433 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
10–383 | flexneri | – | Leu | wt | wt | wt | ND | – | ND | |
10–1166 | flexneri | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
10–929 | boydii | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
10–338 |
dysenteriae |
qnrS1 |
ND |
ND |
ND |
ND |
ND |
– |
ND |
|
2011 | ||||||||||
11–0683 | sonnei | – | wt | Tyr | wt | wt | CTX-M-15 | – | ND | |
11–0616 | flexneri | – | wt | Tyr | wt | wt | ND | – | ND | |
11–0162 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
11–0029 | flexneri | – | Leu | Gly | Ile | wt | ND | – | ND | |
11–1023 |
sonnei |
– |
ND |
ND |
ND |
ND |
CTX-M-15 |
– |
ND |
|
2012 | ||||||||||
12–0580 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
12–0273 | flexneri | – | Leu | Gly | Ile | wt | ND | – | ND | |
12–0094 | dysenteriae | – | Leu | wt | wt | wt | ND | – | ND | |
12–0573 | dysenteriae | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
12–0087 |
flexneri |
qnrS1 |
ND |
ND |
ND |
ND |
ND |
– |
ND |
|
2013 | ||||||||||
13–2304 | flexneri | – | Leu | Gly | Ile | wt | ND | – | ND | |
13–1996 | boydii | – | Leu | wt | wt | Ser | ND | – | ND | |
13–1909 | sonnei | – | wt | Tyr | wt | wt | CTX-M-14 | – | ND | |
13–0136 | flexneri | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
13–1494 | dysenteriae | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
13–1295 | sonnei | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
13–1205 | boydii | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
13–2356 |
boydii |
qnrS1 |
ND |
ND |
ND |
ND |
ND |
– |
ND |
|
2014 | ||||||||||
14–2394 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
14–0754 | flexneri | – | Leu | Asn | Ile | wt | ND | + | 16 | |
14–0369 | sonnei | – | Leu | Gly | Ile | wt | ND | – | ND | |
14–1127 | sonnei | – | ND | ND | ND | ND | CTX-M-15 | – | ND | |
14–1843 | flexneri | – | ND | ND | ND | ND | ND | + | 48 | |
14–1990 | sonnei | qnrB4, qepA | ND | ND | ND | ND | ND | + | >256 | |
14–1929 | sonnei | qnrB19 | ND | ND | ND | ND | ND | – | ND | |
14–1570 | dysenteriae | qnrS1 | ND | ND | ND | ND | ND | – | ND | |
14–1495 | sonnei | – | ND | ND | ND | ND | CTX-M-3 | – | ND | |
14–1820 | sonnei | – | ND | ND | ND | ND | CTX-M-15 | – | ND |
*ESBL, extended-spectrum β-lactamase; ND, not determined; PMQR, plasmid-mediated quinolone resistance; QRDR, quinolone resistance determining regions; wt, wild type; –, negative; +, positive.