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Volume 22, Number 7—July 2016
Online Report

Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus

Timothy M. Uyeki1Comments to Author , Karl J. Erlandson, George Korch, Michael O’Hara, Michael Wathen, Jean Hu-Primmer, Sally Hojvat, Erik J. Stemmy, and Armen Donabedian1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.M. Uyeki); Office of the Assistant Secretary of Preparedness and Response, Washington, DC, USA (K.J. Erlandson, G. Korch, M. O’Hara, M. Wathen, J. Hu-Primmer, A. Donabedian); Food and Drug Administration, Silver Spring, Maryland, USA (S. Hojvat); National Institutes of Health, Rockville, Maryland, USA (E.J. Stemmy)

Main Article

Table 2

Diagnostics candidates for MERS-CoV*

Source Method Status
TIB MolBiol, Berlin, Germany
 upE and ORF1a RT-PCR assays
 Research use only, not for in vitro diagnostic use; company intent to pursue in vitro diagnostic use unknown (32)
Fast-track Diagnostics, Sliema, Malta
 hCoV-EMc
 In vitro diagnostic for use in the European Community (33)
Altona Diagnostics, Hamburg, Germany
 RT-PCR Kit
 In vitro diagnostic for use in the European Community, FDA EUA (31,33)
Primerdesign, Chandler’s Ford, UK
 Novel Coronavirus hCoV-MERS RT-PCR Kit
 Research use only, not for in vitro diagnostic use; company intent to pursue in vitro diagnostic use unknown (33)
US Centers for Disease Control and Prevention, Atlanta, GA, USA Real-time RT-PCR assay Available in all US PHL/LRN laboratories and many international governmental laboratories, FDA EUA (31)

*MERS, Middle East respiratory syndrome; CoV, coronavirus; upE, upstream of E gene; ORF1a, open reading frame 1a polyprotein; RT-PCR, reverse transcription PCR; hCoV-EMc, Human Coronavirus–Erasmus Medical Center/2012; FDA, US Food and Drug Administration; EUA, emergency use authorization; CDC, US Centers for Disease Control and Prevention; PHL/LRN, Public Health Laboratory/Laboratory Response Network.

Main Article

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1These authors contributed equally to this article.

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