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Volume 22, Number 7—July 2016
Online Report

Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus

Timothy M. Uyeki1Comments to Author , Karl J. Erlandson, George Korch, Michael O’Hara, Michael Wathen, Jean Hu-Primmer, Sally Hojvat, Erik J. Stemmy, and Armen Donabedian1
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.M. Uyeki); Office of the Assistant Secretary of Preparedness and Response, Washington, DC, USA (K.J. Erlandson, G. Korch, M. O’Hara, M. Wathen, J. Hu-Primmer, A. Donabedian); Food and Drug Administration, Silver Spring, Maryland, USA (S. Hojvat); National Institutes of Health, Rockville, Maryland, USA (E.J. Stemmy)

Main Article

Table 5

Human vaccine candidates for MERS-CoV targeting spike protein*

Source Vaccine Status
Novavax, Gaithersburg, MD, USA
 Spike protein trimer in 40 nm particle; likely adjuvanted
 Mouse immunogenicity shown (58)
NIAID/Vaccine Research Center, Bethesda, MD, USA
 Two candidate vaccine approaches: DNA spike prime-S1 protein boost and S1 prime-S1 boost
 Mouse and NHP immunogenicity shown; NHP2 (macaque-radiological efficacy shown) (59)
GeneOne Life Science, Seoul, South Korea; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA
 DNA expressing spike; electroporation device
 Mouse, NHP, and camel immunogenicity shown; NHP2 (viremia, lung pathology) (60); phase I study started (61)
Greffex, Aurora, CO, USA
 Fully deleted adenovirus packaging vector
 Mouse immunogenicity (62)
Erasmus University Rotterdam, the Netherlands; University of Marburg, Marburg, Germany; Ludwig-Maximilians University, Munich, Germany
 MVA vectored spike protein
 Mouse immunogenicity and protection shown; clinical trials in planning stage (63,64)
New York Blood Center, New York, NY, USA; Shanghai Medical College, Shanghai, China Spike receptor-binding domain subunit vaccine Recombinant protein containing the 377–588 aa fragment of the S1 subunit (65)

*MERS-CoV, Middle East respiratory syndrome coronavirus; spike, MERS-CoV spike protein; NHP, non -human primate; MVA, modified vaccinia Ankara; S1, portion of spike protein with the receptor binding domain.

Main Article

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1These authors contributed equally to this article.

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