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Volume 22, Number 8—August 2016
Letter

Novel Reassortant Avian Influenza A(H5N6) Viruses in Humans, Guangdong, China, 2015

Yong-Yi Shen1, Chang-Wen Ke1, Qian Li1, Run-Yu Yuan, Dan Xiang, Wei-Xin Jia, Yun-Di Yu, Lu Liu, Can Huang, Wen-Bao Qi, Reina Sikkema, Jie Wu, Marion Koopmans, and Ming LiaoComments to Author 
Author affiliations: Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou (Y.-Y. Shen); College of Veterinary Medicine, South China Agricultural University, Guangzhou, China (Y.-Y. Shen, Q. Li, W.-X. Jia, Y.-D. Yu, W.-B. Qi, M. Liao); Guangdong Provincial Center for Disease Control and Prevention, Guangzhou (C.-W. Ke, R.-Y. Yuan, J. Wu); Shantou University Medical College, Shantou, China (D. Xiang, L. Liu, C. Huang); Key Laboratory of Veterinary Vaccine Innovation of the Ministry of Agriculture, Guangzhou (W.-B. Qi); National Institute of Public Health and the Environment, Bilthoven, the Netherlands (R. Sikkema, M. Koopmans); National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangzhou (M. Liao)

Main Article

Table

Molecular analyses of 5 influenza A(H5N6) virus isolates from humans in China, 2014 and 2015*

Phenotypic consequences Mutations A/Sichuan/ 26221/2014 A/Guangzhou/39715/2014 A/Yunan/ 0127/2015 A/Guangdong/SZ872/2015 A/Guangdong/ZQ874/2015
HA gene
Altered receptor specificity S128P T P P P P
Increased α2,6-SA recognition S137A A A A A A
Removal of the 158N 
glycosylation T160A A T A A A
Q226L Q Q Q Q Q
Cleavage site sequence
 Not applicable
 REKRRKR↓G
 REKRRKR↓G
 REKRRKR↓G
 REKRRKR↓G
 REKRRKR↓G
NA gene
59–69 del TIINNHPQNNF No Yes Yes Yes Yes
Oseltamivir resistance
 H274Y H H H H H
N294S
 N
 N
 N
 N
 N
PB2
Increased pathogenicity in 
mice L89V V V V V V
E627K E K K E E
Increased virulence and 
replication in mice G309D, T339K R477G, I495V DMGV DTGV DKGV DKGV DKGV
Enhanced transmission
 D701N
 N
 D
 D
 D
 N
NS1
Increased virulence in mice 
and pigs D92E E E D D E
PDZ-motif Not applicable ESEV ESEV KPEV KPEV ESEV
Increased virulence in mice
 P42S
 S
 S
 S
 S
 S
M2
Antiviral resistance(amantadine) S31N S S N N S

*HA, hemagglutinin; M2, matrix protein 2; NA, neuraminidase; NS1, nonstructural protein 1; PB2, polymerase basic 2 amino acid.

Main Article

1These authors contributed equally to this article.

Page created: July 15, 2016
Page updated: July 15, 2016
Page reviewed: July 15, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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