Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia
Yaseen M. Arabi
, Ali H. Hajeer, Thomas Luke, Kanakatte Raviprakash, Hanan Balkhy, Sameera Johani, Abdulaziz Al-Dawood, Saad Al-Qahtani, Awad Al-Omari, Fahad Al-Hameed, Frederick G. Hayden1
, Robert Fowler, Abderrezak Bouchama, Nahoko Shindo, Khalid Al-Khairy, Gail Carson, Yusri Taha, Musharaf Sadat, and Mashail Alahmadi
Author affiliations: King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia (Y.M. Arabi, A.H. Hajeer , H. Balkhy, S. Johani, A. Al-Dawood, S. Al-Qahtani, A. Bouchama, K. Al-Khairy, M. Sadat, M. Alahmadi); Naval Medical Research Center, Silver Spring, Maryland, USA (T. Luke, K. Raviprakash); Alfaisal University, Riyadh (A. Al-Omari); King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia (F. Al-Hameed); University of Virginia School of Medicine, Charlottesville, Virginia, USA (F.G. Hayden); University of Toronto, Toronto, Ontario, Canada (R. Fowler); World Health Organization, Geneva, Switzerland (N. Shindo); University of Oxford Centre for Tropical Medicine, Oxford, UK (G. Carson); King Abdulaziz Medical City, Al-Ahsa, Saudi Arabia (Y. Taha)
Figure 2. Clinical and laboratory timeline for a Middle East respiratory coronavirus–infected patient with high ELISA, indirect immunofluorescent antibody (IFA), and microneutralization (MN) titers. The highest titers were measured while the patient had active infection and was critically ill. The ELISA optical density ratio and IFA and MN titers declined as the patient recovered. ICU, intensive care unit; rRT-PCR, real-time reverse transcription PCR; ward, hospital ward; −, negative; +, positive.
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