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Volume 22, Number 9—September 2016
CME ACTIVITY - Synopsis

Treatment Outcomes for Patients with Extensively Drug-Resistant Tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa

Charlotte L. KvasnovskyComments to Author , J. Peter Cegielski, and Martie L. van der Walt
Author affiliations: University of Maryland Medical Center, Baltimore, Maryland, USA (C.L. Kvasnovsky); Medical Research Council of South Africa, South Africa (C.L. Kvasnovsky, M.L. van der Walt); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.P. Cegielski)

Main Article

Table 3

Predictors of favorable outcome among patients initiating treatment for extensively drug-resistant tuberculosis, KwaZulu-Natal and Eastern Cape Provinces, South Africa, 2006–2010*

Predictor Unadjusted analysis
 Multivariate analysis
HR (95% CI) p value HR (95% CI) p value
HIV positive 1.08 (0.59–1.98) 0.81 1.29 (0.60–2.75) 0.52
Previous MDR TB treatment 0.59 (0.33–1.06) 0.08 0.77 (0.35–1.66) 0.50
Smear negative 2.97 (1.41–6.26) 0.004 2.69 (1.29–5.63) 0.009
Age 0.99 (0.97–1.02) 0.55 0.99 (0.96–1.02) 0.58
Weight >50 kg 1.93 (0.93–4.02) 0.08 3.64 (1.68–7.92) 0.001
KwaZulu Province 1.98 (1.12–3.52) 0.02 1.69 (0.81–3.53) 0.16
Male sex 0.57 (0.30–1.09) 0.09 0.77 (0.36–1.67) 0.51
Cavitary disease by chest radiograph 0.61 (0.33–1.10) 0.10 0.50 (0.24–1.03) 0.06

*p values in bold are statistically significant. HR, hazard ratio; MDR TB, multidrug-resistant tuberculosis.

Main Article

Page created: August 11, 2016
Page updated: August 11, 2016
Page reviewed: August 11, 2016
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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