Volume 22, Number 9—September 2016
Letter
Fluoroquinolone-Resistant Mycoplasma genitalium, Southwestern France
Chloé Le Roy, Nadège Hénin, Sabine Pereyre, and Cécile Bébéar
Table
Fluoroquinolone resistance–associated amino acid changes in GyrA and ParC and macrolide resistance–associated mutations in the 23S rRNA gene in Mycoplasma genitalium, France, 2013–2014*
| Patient no. | Date of collection | Patient sex | Specimen type | Mutation in the 23S rRNA gene | Amino acid changes in |
|
|---|---|---|---|---|---|---|
| GyrA | ParC | |||||
| 1 | 2013 Jan 9 | F | Vaginal swab | A2058G/A2059G | NA | NA |
| 2 | 2013 Feb 1 | F | Vaginal swab | A2058G | – | – |
| 3 | 2013 Feb 1 | M | Urethral swab | A2058G/A2059G | Ala-93→Thr | – |
| 4 | 2013 Feb 18 | M | Urethral swab | A2058G/A2059G | – | – |
| 5 | 2013 Feb 20 | M | Urine | A2058G/A2059G | – | – |
| 6 | 2013 Mar 11 | M | Urine | A2058G/A2059G | – | Asp-84→Tyr |
| 7 | 2013 Mar 28 | F | Vaginal swab | A2058G/A2059G | NA | – |
| 8 | 2013 Apr 3 | M | Urine | Wild-type | – | Asp-84→Tyr |
| 9 | 2013 Apr 8 | F | Vaginal swab | A2058G/A2059G | – | – |
| 10 | 2013 Apr 11 | F | Vaginal swab | A2058G/A2059G | NA | NA |
| 11 | 2013 Apr 16 | F | Vaginal swab | A2058G | – | NA |
| 12 | 2013 Apr 19 | F | Vaginal swab | Wild-type | – | Ser-80→Asn |
| 13 | 2013 May 21 | M | Urethral swab | A2059G | – | – |
| 14 | 2013 Jul 4 | M | Urine | A2059G | – | – |
| 15 | 2013 Jul 4 | M | Urethral swab | A2059G | – | – |
| 2013 Jul 19 | M | Urine | A2059G | – | – | |
| 16 | 2013 Jul 19 | M | Urine | A2058G | – | – |
| 17 | 2013 Aug 9 | F | Vaginal swab | A2059G | NA | – |
| 18 | 2013 Sep 30 | F | Vaginal swab | A2058G/A2059G | – | – |
| 19 | 2013 Sep 30 | F | Vaginal swab | A2058G/A2059G | – | – |
| 20 | 2013 Oct 29 | F | Vaginal swab | Wild-type | – | Asn-96→Ser |
| 21 | 2013 Nov 22 | F | Vaginal swab | A2058G/A2059G | NA | NA |
| 22 | 2013 Nov 29 | F | Vaginal swab | A2062T | – | – |
| 23 | 2013 Dec 1 | F | Vaginal swab | Wild-type | – | Asp-84→Tyr |
| 24 | 2014 Jan 21 | F | Vaginal swab | A2059G | – | – |
| 25 | 2014 Jan 29 | F | Vaginal swab | A2059G | – | – |
| 26 | 2014 Jan 30 | F | Vaginal swab | A2058G/A2059G | NA | – |
| 27 | 2014 Feb 13 | F | Vaginal swab | A2059G | – | – |
| 28 | 2014 Feb 18 | M | Urine | Wild-type | – | Ser-80→Ile |
| 29 | 2014 Feb 24 | F | Vaginal swab | Wild-type | – | Asp-84→Asn |
| 30 | 2014 Mar 5 | F | Vaginal swab | Wild-type | – | Asp-84→Asn |
| 31 | 2014 Mar 14 | M | Urine | NA | – | Ser-80→Asn |
| 32 | 2014 Apr 3 | F | Endocervical swab | A2058G | – | – |
| 33 | 2014 Apr 7 | M | Urethral swab | A2059G | – | – |
| 34 | 2014 Jun 24 | F | Vaginal swab | A2059C | – | – |
| 35 | 2014 Jul 9 | F | Endocervical swab | A2059G | NA | – |
| 36 | 2014 Jul 25 | F | Urine | A2058G/A2059G | NA | NA |
| 37 | 2014 Jul 25 | F | Vaginal swab | A2058G | – | – |
| 38 | 2014 Aug 19 | F | Endocervical swab | A2062T | – | NA |
| 39 | 2014 Aug 28 | F | Vaginal swab | A2058G/A2059G | – | – |
| 40 | 2014 Sep 24 | F | Vaginal swab | A2059G | – | – |
| 41 | 2014 Oct 7 | F | Vaginal swab | A2059G | – | – |
| 42 | 2014 Oct 15 | F | Vaginal swab | A2058G/A2059G | – | – |
| 43 | 2014 Oct 31 | M | Urine | A2058G | – | – |
| 44 | 2014 Nov 5 | F | Vaginal swab | A2058G/A2059G | NA | – |
| 45 | 2014 Nov 28 | F | Vaginal swab | A2058G | – | – |
| 46 | 2014 Dec 3 | F | Vaginal swab | Wild-type | – | Asp-84→Asn |
| 47 | 2014 Dec 3 | M | Urethral swab | Wild-type | – | Asp-84→Asn |
| 48 |
2014 Dec 4 |
M |
Urine |
A2059G |
– |
– |
| *A2058/A2059G indicates a macrolide–resistant (A2058G or A2059G) genotype. Positions in the 23S rRNA and in GyrA and ParC are identified according to Escherichia coli numbering. NA, not available; –, no amino acid change. | ||||||
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