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Volume 22, Number 9—September 2016
Letter

Possible Transmission of mcr-1–Harboring Escherichia coli between Companion Animals and Human

Xue-Fei Zhang, Yohei Doi, Xi Huang, Hong-Yu Li, Lan-Lan Zhong, Kun-Jiao Zeng, Yan-Fen Zhang, Sandip Patil, and Guo-Bao TianComments to Author 
Author affiliations: Sun Yat-Sen University Zhongshan School of Medicine, Guangzhou, China (X.-.F Zhang, X. Huang, L.-L. Zhong, K.-J. Zeng, Y.-F. Zhang, S. Patil, G.-B. Tian); Ministry of Education Key Laboratory of Tropical Diseases Control, Guangzhou (X.-F. Zhang, X. Huang, L.-L. Zhong, K.-J. Zeng, Y.-F. Zhang, S. Patil, G.-B. Tian); University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Y. Doi); Sun Yat-Sen University Memorial Hospital, Guangzhou (H.-Y. Li)

Main Article

Table

Characteristics of 9 mcr-1–positive Escherichia coli isolates from companion animals and human patients, Guangzhou, China

Characteristic Isolate
PET01 PET02 PET03 PET04 PET05 PET06 EC07 EC08 EC09
Isolation date
 2016 Jan 1
 2016 Jan 1
 2016 Jan 2
 2016 Jan 2
 2016 Jan 2
 2016 Jan 4
 2015 Oct 10
 2015 Nov 2
 2015 Nov 21
Specimen source
 Cat
 Dog
 Dog
 Dog
 Cat
 Dog
 Human
 Human
 Human
Specimen type
 Feces
 Feces
 Feces
 Feces
 Feces
 Feces
 Urine
 Urine
 Blood
Phylogenetic group
 B2
 D
 D
 D
 B2
 D
 D
 B1
 B1
ST†
 ST93
 ST354
 ST354
 ST354
 New
 ST354
 ST354
 ST156
 ST156
PFGE type
 IV
 I
 I
 I
 V
 I
 I
 II
 III
Resistance genes
 mcr-1, blaTEM-1, qepA
 mcr-1, blaTEM-1, blaCTX-M-15, fosA3, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaCTX-M-15, fosA3, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaCTX-M-15, fosA3, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaSHV-12, blaCTX-M-15, fosA3, rmtB, qnrS, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaCTX-M-15, fosA3, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaCTX-M-15, fosA3, aac(6′)-Ib-cr
 mcr-1, blaTEM-1, blaCTX-M-55, fosA3, rmtB, qepA1
 mcr-1, blaIMP-4, blaTEM-1, blaCTX-M-55, fosA3, rmtB, qepA1
MIC, μg/mL
Colistin 16 8 8 16 16 8 8 8 64
Polymyxin B 16 16 16 32 16 16 8 8 64
Ampicillin >256 >256 >256 >256 >256 >256 >256 >256 >256
AMX/CLV 16 32 32 32 256 16 32 16 16
Cefotaxime 64 >256 256 >256 256 >256 256 256 >256
Ceftazidime 16 256 128 256 64 256 128 32 >256
Cefepime 8 256 128 256 16 256 64 64 >256
Gentamicin 128 >256 >256 >256 256 >256 >256 >256 >256
Amikacin 4 >256 >256 >256 >256 >256 >256 >256 >256
Ertapenem <0.25 1 0.5 0.25 <0.25 1 0.5 <0.25 >16
Imipenem <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 >16
Meropenem <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 <0.25 >16
Fosfomycin 32 >512 >512 >512 >512 >512 >512 >512 >512
Tigecycline <2 <2 <2 <2 <2 <2 <2 <2 4
Nitrofurantoin <16 32 32 32 128 32 64 64 32
Ciprofloxacin 256 128 128 128 64 128 128 256 256

*AMX/CLV, amoxicillin clavulanic acid; PFGE, pulsed-field gel electrophoresis; ST, sequence type.
†By multilocus sequence typing.

Main Article

Page created: August 16, 2016
Page updated: August 16, 2016
Page reviewed: August 16, 2016
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