Chromosomal Locations of mcr-1 and blaCTX-M-15 in Fluoroquinolone-Resistant Escherichia coli ST410
Linda Falgenhauer, Said-Elias Waezsada, Konrad Gwozdzinski, Hiren Ghosh, Swapnil Doijad, Boyke Bunk, Cathrin Spröer, Can Imirzalioglu, Harald Seifert, Alexandra Irrgang, Jennie Fischer, Beatriz Guerra1
, Annemarie Käsbohrer, Jörg Overmann, Alexander Goesmann, and Trinad Chakraborty
Author affiliations: Justus Liebig University, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, A. Goesmann, T. Chakraborty); German Center for Infection Research, Giessen, Germany (L. Falgenhauer, S.-E. Waezsada, K. Gwozdzinski, H. Ghosh, S. Doijad, C. Imirzalioglu, T. Chakraborty); Leibniz Institute DSMZ—German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany (B. Bunk, C. Spröer, J. Overmann); German Center for Infection Research, Braunschweig (B. Bunk, C. Spröer, J. Overmann); University of Cologne, Cologne, Germany (H. Seifert); German Center for Infection Research, Cologne (H. Seifert); Federal Institute for Risk Assessment, Berlin, Germany (A. Irrgang, J. Fischer, B. Guerra, A. Käsbohrer)
Figure. A) Genetic environment of mcr-1 in extended-spectrum β–lactamase (ESBL)–producing food isolates including the original environment found in pHNSHP45. Colors represent gene functions and insertion sequences: purple, transposase of ISApl1; dark blue, ISApl1 element; green, mcr-1; pink, hypothetical protein within the mcr-1 transposition unit; red, light blue, yellow, flanking genes specific for the respective isolate. B) Phylogenetic tree (unrooted) of the Escherichia coli sequence type 410 isolates harboring the blaCTX-M-15 transposition unit in the chromosome and a schematic depiction of the location of the mcr-1 and blaCTX-M-15 transposition unit. Isolates prefixed with the letter E represent consecutive isolates from 1 patient. Scale bar indicates nucleotide substitutions per site.
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