Norovirus Infection in Harbor Porpoises
Miranda de Graaf
, Rogier Bodewes
1, Cornelis E. van Elk, Marco van de Bildt, Sarah Getu, Georgina I. Aron, Georges M.G.M. Verjans, Albert D.M.E. Osterhaus, Judith M.A. van den Brand, Thijs Kuiken, and Marion P.G. Koopmans
Author affiliations: Erasmus Medical Centre, Rotterdam, the Netherlands (M. de Graaf, R. Bodewes, C.E. van Elk, M. van de Bildt, S. Getu, G.I. Aron, G.M.G.M. Verjans, J.M.A. van den Brand, T. Kuiken, M.P.G. Koopmans); Dolphinarium Harderwijk, Harderwijk, the Netherlands (C.E. van Elk); SOS Dolphin Foundation, Harderwijk, the Netherlands (C.E. van Elk); University of Veterinary Medicine, Hannover, Germany (A.D.M.E. Osterhaus)
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Figure 1
Figure 1. Genetic characterization of harbor porpoise norovirus. A) Genome organization of harbor porpoise norovirus. The putative cleavage sites are shown with arrowheads. B, C) Maximum-likelihood trees of the RNA-dependent RNA-polymerase (B) and ORF 2 (C) were inferred by PhyML 3.0 software (http://www.atgc-montpellier.fr/phyml/) by using the general time reversible nucleotide substitution model. Selected bootstrap values >70 are depicted. Scale bars indicate nucleotide substitutions per site. NS, nonstructural; NTPase, nucleoside triphosphatase; ORF, open reading frame; P, protein; Pol, polymerase; Pro, protease; VP, viral protein.
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