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Volume 23, Number 10—October 2017


Antimicrobial Drug Prescription and Neisseria gonorrhoeae Susceptibility, United States, 2005–2013

Robert D. KirkcaldyComments to Author , Monina G. Bartoces, Olusegun O. Soge, Stefan Riedel, Grace Kubin, Carlos Del Rio, John Papp, Edward W. Hook, and Lauri A. Hicks
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.D. Kirkcaldy, M.G. Bartoces, J.R. Papp, L.A. Hicks); University of Washington, Seattle, Washington, USA (O.O. Soge); Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA (S. Riedel); Texas Department of State Health Services, Austin, Texas, USA (G. Kubin); Emory University, Atlanta (C. Del Rio); University of Alabama at Birmingham, Birmingham, Alabama, USA (E.W. Hook III)

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Table 2

Adjusted linear regression coefficients for change in antimicrobial geometric mean MIC associated with 10% increase in corresponding antimicrobial prescribing rate for 23 sites, Gonococcal Isolate Surveillance Project, United States, 2005–2013*

Effect β coefficient SE d.f. 95% CI of β coefficient
  Time −0.0087 0.003 155 −0.0146, −0.0029
  Macrolide prescribing†
−0.0502, 0.0191
  Time 0.0011 0.0001 109 0.0008, 0.0014
  Cephalosporin prescribing‡
−0.0010, 0.0041
  Time 0.0004 0.0001 155 0.0002, 0.0005
  Cephalosporin prescribing‡
−0.0009, 0.0013
  Time 0.0004 0.0021 155 −0.0038, 0.0045
  Fluoroquinolone prescribing§ 0.0004 0.0230 155 −0.0451, 0.0458

*All models were adjusted for percent of MSM at each site (using GISP data), race (percentage of men coded as black versus non-black in GISP data) percentage,and geographic region. Time was based on 1-year intervals. Estimate is statistically significant if the 95% CI of β coefficient does not cross 0.
†Per 10% increase in macrolide prescribing during the previous year; includes azithromycin, clarithromycin, and erythromycin.
‡Per 10% increase in cephalosporin prescribing during the previous year; includes cefaclor, cefadroxil, cefdinir, cefditoren pivoxil, cefixime, cefpodoxime proxetil, cefprozil, ceftibuten, cefuroxime axetil, cephalexin, cephradine, and loracarbef.
§Per 10% increase in fluoroquinolone prescribing during the previous year; includes ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, and trovafloxacin.

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