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Volume 23, Number 11—November 2017

Symptom- and Laboratory-Based Ebola Risk Scores to Differentiate Likely Ebola Infections

Shefali OzaComments to Author , Alieu A. Sesay, Neal J. Russell, Kevin Wing, Sabah Boufkhed, Lahai Vandi, Sahr C. Sebba, Rachael Cummings, and Francesco Checchi
Author affiliations: Save the Children International, Kerry Town, Sierra Leone (S. Oza, A.A. Sesay, N.J. Russell, K. Wing, S. Boufkhed, L. Vandi, S.C. Sebba, R. Cummings, F. Checchi); London School of Hygiene and Tropical Medicine, London, United Kingdom (S. Oza, N.J. Russell, K. Wing, S. Boufkhed, F. Checchi); Save the Children International, London (R. Cummings, F. Checchi)

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Table 3

Factors included in ESR and ESLR scores to determine risk for infection in suspected Ebola patients*

Factor Coefficient (95% CI) from multivariable model† p value Score value
Symptoms, for ESR and ESLR scores
Conjunctivitis 1.44 (0.93 to 1.95) <0.001 +2
Diarrhea 1.11 (0.60 to 1.61) <0.001 +2
Nausea/vomiting 0.78 (0.24 to 1.31) 0.005 +1
Headache −0.45 (−0.98 to 0.09) 0.103 −1
Difficulty breathing −1.60 (−2.11 to 1.10) <0.001 −1
Loss of appetite
−1.90 (−2.60 to −1.20)
Laboratory tests if available, for ESLR score only
Alanine transaminase >48 U/L 3.83 (2.67 to 5.00) <0.001 +2
Creatine kinase >380 U/L 1.78 (0.73 to 2.84) 0.001 +2
Creatinine >106 μmol/L −1.15 (−2.21 to −0.09) 0.033 −1
Total bilirubin >27 μmol/L −1.81 (−3.24 to −0.39) 0.012 −1

*ESLR, Ebola symptom- and laboratory-based risk; ESR, Ebola symptom-based risk.
†Laboratory tests have been adjusted for the symptom predictors. Coefficient values are before normalization.

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Page created: October 16, 2017
Page updated: October 16, 2017
Page reviewed: October 16, 2017
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