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Volume 23, Number 11—November 2017
Dispatch

Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan

Hasan Ejaz12, Nancy Wang1, Jonathan J. Wilksch, Andrew J. Page, Hanwei Cao, Shruti Gujaran, Jacqueline A. Keane, Trevor Lithgow, Ikram ul-Haq, Gordon Dougan, Richard A. Strugnell1Comments to Author , and Eva Heinz1Comments to Author 
Author affiliations: CAMS, Aljouf University, Aljouf, Saudi Arabia; The Children’s Hospital, Lahore, Pakistan (H. Ejaz); The University of Melbourne, Melbourne, Victoria, Australia (H. Ejaz, N. Wang, J.J. Wilksch, H. Cao, S. Gujaran, R.A. Strugnell); Wellcome Trust Sanger Institute, Hinxton, UK (A.J. Page, J.A. Keane, G. Dougan, E. Heinz); Monash University, Melbourne (T. Lithgow, E. Heinz); Government College University, Lahore (I.ul-Haq)

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Figure 2

Phylogenetic analysis demonstrating the diversity of Klebsiella pneumoniae isolates from clinical samples collected during May 2010–February 2012 from The Children’s Hospital & The Institute of Child Health, Lahore, Pakistan, in a global context. The core gene tree based on the alignment derived from Roary (12) was calculated using RAxML (14) and shows the wide diversity of samples analyzed in this study (inner ring, yellow) in context with a large-scale global analysis (inner ring, blue [4]

Figure 2. Phylogenetic analysis demonstrating the diversity of Klebsiella pneumoniae isolates from clinical samples collected during May 2010–February 2012 from The Children’s Hospital & The Institute of Child Health, Lahore, Pakistan, in a global context. The core gene tree based on the alignment derived from Roary (12) was calculated using RAxML (14) and shows the wide diversity of samples analyzed in this study (inner ring, yellow) in context with a large-scale global analysis (inner ring, blue [4]) and 2 hospital outbreaks, which show a more clonal pattern (inner ring: red, outbreak in Spain [11]; green, outbreak in Nepal [3]). The sequence types observed (outer ring) also reflect the diversity; most sequence types have <10 members even in this combined collection. STs, sequence types.

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1These authors contributed equally to this article.

2Current affiliation: CAMS, Aljouf University, Aljouf, Saudi Arabia.

Page created: October 17, 2017
Page updated: October 17, 2017
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