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Volume 23, Number 11—November 2017
Dispatch

High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium

Yan Guo, Adam D. Tomich, Christi L. McElheny, Vaughn S. Cooper, Amelia Tait-Kamradt, Min Chen, Fupin Hu, Louis B. Rice, Nicolas Sluis-Cremer, and Yohei DoiComments to Author 
Author affiliations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (Y. Guo, A.D. Tomich, C.L. McElheny, V.S. Cooper, N. Sluis-Cremer, Y. Doi); Fudan University Huashan Hospital, Shanghai, China (Y. Guo, M. Wang, F. Hu); Brown University, Providence, Rhode Island, USA (A. Tait-Kamradt, L.B. Rice); Fujita Health University, Aichi, Japan (Y. Doi)

Main Article

Figure

Inhibition of recombinant purified vancomycin-resistant Enterococcus faecium wild-type (A) and C119D (B) MurA by fosfomycin. The 50% inhibitory concentration was 176.8 ± 38.3 nmol/L for wild-type MurA and >100 μmol/L for C119D MurA. Error bars indicate mean ± SD of >3 independent experiments. MurA, UDP-N-acetylglucosamine enolpyruvyl transferase.

Figure. Inhibition of recombinant purified vancomycin-resistant Enterococcus faecium wild-type (A) and C119D (B) MurA by fosfomycin. The 50% inhibitory concentration was 176.8 ± 38.3 nmol/L for wild-type MurA and >100 μmol/L for C119D MurA. Error bars indicate mean ± SD of >3 independent experiments. MurA, UDP-N-acetylglucosamine enolpyruvyl transferase.

Main Article

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Page updated: October 17, 2017
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