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Volume 23, Number 12—December 2017

Research Letter

Detection of Zika Virus in April 2013 Patient Samples, Rio de Janeiro, Brazil

Sonia R. Lambert PassosComments to Author , Maria A. Borges dos Santos, José Cerbino-Neto, Sibelle N. Buonora, Thiago M.L. Souza, Raquel V.C. de Oliveira, Alexandre Vizzoni, Giselle Barbosa-Lima, Yasmine R. Vieira, Marcondes Silva de Lima, and Yara H. M. Hökerberg
Author affiliations: Oswaldo Cruz Foundation, Rio de Janeiro, Brazil (S.R.L. Passos, T.M.L. Souza); Estácio de Sá University, Rio de Janeiro (S.R.L. Passos, Y.H.M. Hökerberg); Fundação Oswaldo Cruz Escola Nacional de Saúde Pública, Rio de Janeiro (M.A. Borges dos Santos); Evandro Chagas National Institute of Infectious Diseases, Rio de Janeiro (J. Cerbino-Neto, S.N. Buonora, R.V.C. de Oliveira, A. Vizzoni, G. Barbosa-Lima, Y.R. Vieira, M.S. de Lima, Y.H.M. Hökerberg); Universidade Federal do Rio de Janeiro, Rio de Janeiro (S.N. Buonora)

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Distribution of clinical signs and symptoms among 3 patients retrospectively identified as having Zika virus infection, Rio de Janeiro, Brazil, 2013*

No. patients, sign or symptom Patient A Patient B Patient C
3 patients
Arthralgia† Yes Yes Yes
Fever†, no. days Yes, 1 Yes, 2 Yes, 1
Headache Yes Yes Yes
Myalgia Yes Yes Yes
Nausea Yes Yes Yes
Prostration Yes Yes Yes
Retroorbital pain
2 patients
Adenomegaly Yes Yes No
Chills Yes No Yes
Dizziness Yes Yes No
Low back pain No Yes Yes
Taste alteration Yes Yes No
1 patient
Anorexia No No Yes
Cold extremities Yes No No
Cough Yes No No
Dyspnea No Yes No
Eye congestion No Yes No
Eye redness perception† No Yes No
Hemoconcentration No No Yes
Hoarseness No Yes No
Leukopenia No Yes No
Oropharyngeal pain Yes No No
Otalgia No Yes No
Pruritus No Yes No
Thready pulse Yes No No

*No patients had exanthema.
†Signs and symptoms considered in Brazilian Ministry of Health’s definition for suspected Zika virus infection (

Main Article