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Volume 23, Number 2—February 2017

Dispatch

Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant Candida auris

Leighann Sherry, Gordon Ramage, Ryan Kean, Andrew Borman, Elizabeth M. Johnson, Malcolm D. Richardson, and Riina Rautemaa-RichardsonComments to Author 
Author affiliations: University of Glasgow, Glasgow, Scotland, UK (L. Sherry, G. Ramage, R. Kean); Public Health England, Bristol, UK (A. Borman, E.M. Johnson); The University of Manchester, Manchester, UK (M.D. Richardson, R. Rautemaa-Richardson); University Hospital of South Manchester, Manchester (M.D. Richardson, R. Rautemaa-Richardson)

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Table 2

Sessile susceptibility profiles of 7 antifungals against Candida auris yeast

Drug
Sessile MIC*
Strain 2
Strain 6
Strain 10
Strain 12
Fluconazole >32 >32 >32 >32
Voriconazole >32 >32 >32 >32
Caspofungin >32 >32 >32 >32
Micafungin >32 >32 0.25 >32
Liposomal amphotericin B 2 8 16 16
Amphotericin B 2 4 2 4
Chlorhexidine, % <0.02 <0.02 <0.02 <0.02

*Values are mg/L except as indicated. Sessile MICs are defined as a 90% inhibition of the metabolic dye XTT, 2,3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt (Sigma-Aldrich, Dorset, UK) compared with the untreated control; MIC tests were performed on 3 independent occasions and showed identical results each time.

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