Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 2—February 2017
Dispatch

Neisseria meningitidis ST11 Complex Isolates Associated with Nongonococcal Urethritis, Indiana, USA, 2015–2016

Evelyn Toh1, Dharanesh Gangaiah1, Byron E. Batteiger, James A. Williams, Janet N. Arno, Albert Tai, Teresa A. Batteiger, and David E. NelsonComments to Author 
Author affiliations: Indiana University School of Medicine, Indianapolis, Indiana, USA (E. Toh, D. Gangaiah, B.E. Batteiger, J.A. Williams, J.N. Arno, T.A. Batteiger, D.E. Nelson); Tufts University School of Medicine, Boston, Massachusetts, USA (A. Tai).

Main Article

Figure

Rooted phylogenetic tree of Neisseria meningitidis sequence type 11 urethral isolates from men in Indianapolis, Indiana, USA, 2015–2016, compared with representative serogroup strains of N. meningitidis. Tree was inferred by using the neighbor-joining method constructed with MEGA7 (13). The percentage of replicate trees in which the associated taxa clustered together in 500 bootstrap tests is indicated next to the branches. The tree is drawn to scale, and branch lengths correspond to evolutionar

Figure. Rooted phylogenetic tree of Neisseria meningitidis sequence type 11 urethral isolates from men in Indianapolis, Indiana, USA, 2015–2016, compared with representative serogroup strains of N. meningitidis. Tree was inferred by using the neighbor-joining method constructed with MEGA7 (13). The percentage of replicate trees in which the associated taxa clustered together in 500 bootstrap tests is indicated next to the branches. The tree is drawn to scale, and branch lengths correspond to evolutionary distances used to infer the phylogenetic tree. Arrow indicates urethritis strains NM1 and NM2. GC strain FA1090 was used as the outgroup. Scale bar indicates nucleotide substitutions per site.

Main Article

References
  1. Feldman  HA. Meningococcus and gonococcus: never the Twain—well, hardly ever. N Engl J Med. 1971;285:518–20. DOIPubMedGoogle Scholar
  2. Carpenter  CM, Charles  R. Isolation of meningococcus from the genitourinary tract of seven patients. Am J Public Health Nations Health. 1942;32:640–3. DOIPubMedGoogle Scholar
  3. Murray  E. Meningococcus infections of the male urogenital tract and the liability to confusion with gonococcus infection. Urol Cutaneous Rev. 1939;43:739–41.
  4. Janda  WM, Bohnoff  M, Morello  JA, Lerner  SA. Prevalence and site-pathogen studies of Neisseria meningitidis and N gonorrhoeae in homosexual men. JAMA. 1980;244:2060–4. DOIPubMedGoogle Scholar
  5. Nebreda  T, Campos  A, Merino  FJ. Urethritis caused by Neisseria meningitidis serogroup C. Clin Microbiol Infect. 1999;5:57–60. DOIPubMedGoogle Scholar
  6. Rodriguez  CN, Rodriguez-Morales  AJ, Garcia  A, Pastran  B, Rios  A, Calvo  A, et al. Quinolone and azithromycin-resistant Neisseria meningitidis serogroup C causing urethritis in a heterosexual man. Int J STD AIDS. 2005;16:649–50. DOIPubMedGoogle Scholar
  7. Gregory  JE, Crook  R, Keeler  G. Urethritis attributable to Neisseria meningitidis, group X: a case report. J Natl Med Assoc. 1979;71:845–6.PubMedGoogle Scholar
  8. Hayakawa  K, Itoda  I, Shimuta  K, Takahashi  H, Ohnishi  M. Urethritis caused by novel Neisseria meningitidis serogroup W in man who has sex with men, Japan. Emerg Infect Dis. 2014;20:1585–7. DOIPubMedGoogle Scholar
  9. Hagman  M, Forslin  L, Moi  H, Danielsson  D. Neisseria meningitidis in specimens from urogenital sites. Is increased awareness necessary? Sex Transm Dis. 1991;18:228–32. DOIPubMedGoogle Scholar
  10. Shanmugaratnam  K, Pattman  RS. Acute urethritis due to Neisseria meningitidis. Genitourin Med. 1989;65:401–2.PubMedGoogle Scholar
  11. Bazan  JA, Peterson  AS, Kirkcaldy  RD, Briere  EC, Maierhofer  C, Turner  AN, et al. Notes from the field: Increase in Neisseria meningitidis–associated urethritis among men at two sentinel clinics—Columbus, Ohio, and Oakland County, Michigan, 2015. MMWR Morb Mortal Wkly Rep. 2016;65:550–2. DOIPubMedGoogle Scholar
  12. Bratcher  HB, Corton  C, Jolley  KA, Parkhill  J, Maiden  MC. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014;15:1138. DOIPubMedGoogle Scholar
  13. Kumar  S, Stecher  G, Tamura  K. MEGA7: Molecular Evolutionary Genetics Analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33:1870–4. DOIPubMedGoogle Scholar
  14. Harrison  OB, Claus  H, Jiang  Y, Bennett  JS, Bratcher  HB, Jolley  KA, et al. Description and nomenclature of Neisseria meningitidis capsule locus. Emerg Infect Dis. 2013;19:566–73. DOIPubMedGoogle Scholar
  15. Corless  CE, Guiver  M, Borrow  R, Edwards-Jones  V, Fox  AJ, Kaczmarski  EB. Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J Clin Microbiol. 2001;39:1553–8. DOIPubMedGoogle Scholar

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2017
Page updated: January 17, 2017
Page reviewed: January 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external