Volume 23, Number 3—March 2017
Dispatch
Molecular Evidence of Drug Resistance in Asymptomatic Malaria Infections, Myanmar, 2015
Table
Plasmodium falciparum and P. vivax drug-resistance molecular markers in asymptomatic infections, Myanmar, 2015
Target | Description* | No. isolates/total (%) |
---|---|---|
kelch 13 (K13) |
Wild | 2/4 (50.0) |
C580Y | 1/4 (25.0) | |
P574L |
1/4 (25.0) |
|
P. falciparum apicoplast ribosomal protein S10 (pfarps10) |
Wild | 2/4 (50.0) |
V127M |
2/4 (50.0) |
|
P. falciparum ferredoxin (pffd) |
Wild | 1/4 (25.0) |
D193Y |
3/4 (75.0) |
|
P. falciparum multidrug-resistance protein 2 (pfmdr2) |
Wild | 0/4 (0.0) |
T484I |
4/4 (100.0) |
|
P. vivax chloroquine-resistance transporter (pvcrt-o) |
Wild | 7/21 (33.3) |
Mutant (AAG insert) |
14/21 (66.7) |
|
P. vivax multidrug-resistance protein 1 (pvmdr1) |
Wild (T, Y, F) (958, 976, 1076) | 0/21 (0.0) |
Double mutant (M,Y, L) | 4/21 (19.0) | |
Single mutant (M, Y, F) | 12/21 (57.1) | |
Triple mutant (M, F, L) |
5/21 (23.8) |
|
P. vivax dihydropteroate synthase (pvdhps) |
Wild (S, A, K, A) (382, 383, 512, 553) | 0/20 (0.0) |
Single mutant (S, G, K, A) | 4/20 (20.0) | |
Double mutant (S, G, K, G) | 9/20 (45.0) | |
Triple mutant (A, G, K, G) | 5/20 (25.0) | |
Quadruple mutant (A, G, M, G) |
2/20 (10.0) |
|
P. vivax dihydrofolate reductase (pvdhfr) | Wild (F, S, T, S) (57, 58, 61, 117) | 0/21 (0.0) |
Single mutant (L, S, T, S) | 1/21 (4.8) | |
Double mutant (F, R, T, N) | 2/21 (9.5) | |
Quadruple mutant (L/I, R, M, T) | 18/21 (85.7) |
*Numbers in parentheses indicate the amino acid position. Mutant amino acids are shown in bold. All sequences were aligned with 3D7 (P. falciparum) and Sal-1 (P. vivax) reference sequences from http://www.plasmodb.org.
1These authors contributed equally to this article.