Volume 23, Number 3—March 2017
CME ACTIVITY - Synopsis
Epidemiology of Mycobacterium bovis Disease in Humans in England, Wales, and Northern Ireland, 2002–2014
Jennifer A. Davidson
, Miranda G. Loutet, Catherine O’Connor, Cathriona Kearns, Robert M.M. Smith, Maeve K. Lalor, H. Lucy Thomas, Ibrahim Abubakar, and Dominik Zenner
, Miranda G. Loutet, Catherine O’Connor, Cathriona Kearns, Robert M.M. Smith, Maeve K. Lalor, H. Lucy Thomas, Ibrahim Abubakar, and Dominik Zenner
Table 2
Demographics and risk factors for patients with Mycobacterium tuberculosis and M. bovis disease, England, Wales, and Northern Ireland, 2002–2014*
| Characteristic |
M. bovis patients, no. (%), n = 329 |
M. tuberculosis patients, no. (%), n = 58,540 |
Univariable analysis |
Multivariable analysis |
|||
| OR (95% CI) |
p value |
OR (95% CI) |
p value |
||||
| Age group, y | |||||||
| 0–14 | 6 (1.8) | 1,200 (2.1) | 1.9 (0.8–4.3) | <0.001 | 1.5 (0.6–3.6) | <0.001 | |
| 15–44 | 102 (31.0) | 38,558 (65.9) | Referent | Referent | |||
| 45–64 | 61 (18.5) | 10,953 (18.7) | 2.1 (1.5–2.9) | 1.3 (0.9–2.0) | |||
| >65 |
160 (48.6) |
7,826 (13.4) |
7.7 (6.0–9.9) |
3.6 (2.6–5.2) |
|||
| Sex | |||||||
| M | 179 (54.4) | 33,715 (57.7) | 0.9 (0.7–1.1) | 0.229 | 0.9 (0.7–1.1) | 0.287 | |
| F |
150 (45.6) |
24,721 (42.3) |
Referent |
Referent |
|||
| UK-born | |||||||
| Yes | 214 (72.1) | 13,576 (24.7) | 7.9 (6.1–10.1) | <0.001 | 2.6 (1.7–4.1) | <0.001 | |
| No |
83 (27.9) |
71,361 (75.3) |
Referent |
Referent |
|||
| Ethnicity | |||||||
| White | 230 (73) | 11,968 (21.1) | 28.0 (16.8–46.4) | <0.001 | 14.6 (7.2–26.9) | <0.001 | |
| Black African | 37 (11.8) | 12,501 (22.1) | 4.3 (2.4–7.7) | 7.4 (3.7–14.9) | |||
| Indian subcontinent† | 16 (5.1) | 23,285 (41.1) | Referent | Referent | |||
| Other |
32 (10.2) |
8,905 (15.7) |
5.2 (2.9–9.5) |
7.3 (3.6–14.8) |
|||
| Occupation | |||||||
| Agricultural/animal contact work | 20 (7.9) | 116 (0.3) | 32.4 (19.8–53.0) | <0.001 | 29.5 (16.9–51.6) | <0.001 | |
| Other |
232 (92.1) |
43,698 (99.7) |
Referent |
Referent |
|||
| Site of disease | |||||||
| Pulmonary | 193 (58.8) | 37,580 (64.2) | 0.8 (0.6–1.0) | 0.048 | 0.4 (0.3–0.5) | <0.001 | |
| Extrapulmonary only |
135 (41.2) |
20,938 (35.8) |
Referent |
Referent |
|||
| Place of residence | |||||||
| Rural | 81 (24.6) | 1,944 (3.3) | 9.5 (7.3–12.2) | <0.001 | 2.8 (2.0–3.9) | <0.001 | |
| Urban | 248 (75.4) | 56,380 (96.7) | Referent | Referent | |||
*Interactions between 1) place of birth (UK-born/non–UK-born) and all of the other variables (age, sex, ethnicity, occupation, site of disease, place of residence [rural/urban]) and 2) age and site of disease or place of residence (rural/urban) were tested. No significant interactions existed in the model.
OR, odds ratio.
†Indian, Bangladeshi, and Pakistani ethnic groups.
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