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Volume 23, Number 4—April 2017
Research Letter

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection

Dennis TappeComments to Author , José Vicente Pérez-Girón1, Sergio Gómez-Medina, Stephan Günther, César Muñoz-Fontela, and Jonas Schmidt-Chanasit
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, S. Günther, C. Muñoz-Fontela, J. Schmidt-Chanasit); German Centre for Infection Research, Hamburg (D. Tappe, S. Günther, C. Muñoz-Fontela, J. Schmidt-Chanasit); Leibniz Institute for Experimental Virology, Hamburg (J.V. Pérez-Girón, S. Gómez-Medina, C. Muñoz-Fontela)

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Table

Returning travelers from Australia infected with Ross River virus included in study of cytokine levels during acute and convalescent disease phases, Germany

Patient no. Age, y/sex Timing of cytokine level testing after symptom onset IgM titer* IgG titer*
1 33/M 8 wk 1:320 1:320
2 67/F 7 wk 1:80 1:1,280
3 55/F 4 wk 1:2,560 1:1,280
4 24/M 10 and 13 wk 1:320 each 1:2,560
5 29/F 6 wk 1:2560 1:10,240
6 21/F 6 wk 1:80 1:1,280
7 46/M 5 d 1:2,560 1:80
8 31/F 1 wk 1:10,240 1:160
9 32/F 2 wk 1:81,900 1:327,680
10 51/F 4 and 8 wk 1:320 and 1:160 1:2,560 and 1:640
11 20/F 6 wk 1:320 1:2,560
12 47/M 8 wk 1:160 1:320
13 32/M 16 wk 1:20 1:160
14 43/F 8 wk 1:320 1:2,560
15 53/M 3 d, 2 wk, and 9 wk 1:320, 1:10,240, and 1:640 1:20, 1:1,280, and 1:320
16 49/F 6 wk 1:1,280 1:2,560

*By indirect immunofluorescence testing; reference value <1:20 (2).

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References
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1Deceased.

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