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Volume 23, Number 4—April 2017
Research Letter

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection

Dennis TappeComments to Author , José Vicente Pérez-Girón1, Sergio Gómez-Medina, Stephan Günther, César Muñoz-Fontela, and Jonas Schmidt-Chanasit
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, S. Günther, C. Muñoz-Fontela, J. Schmidt-Chanasit); German Centre for Infection Research, Hamburg (D. Tappe, S. Günther, C. Muñoz-Fontela, J. Schmidt-Chanasit); Leibniz Institute for Experimental Virology, Hamburg (J.V. Pérez-Girón, S. Gómez-Medina, C. Muñoz-Fontela)

Main Article

Table

Returning travelers from Australia infected with Ross River virus included in study of cytokine levels during acute and convalescent disease phases, Germany

Patient no. Age, y/sex Timing of cytokine level testing after symptom onset IgM titer* IgG titer*
1 33/M 8 wk 1:320 1:320
2 67/F 7 wk 1:80 1:1,280
3 55/F 4 wk 1:2,560 1:1,280
4 24/M 10 and 13 wk 1:320 each 1:2,560
5 29/F 6 wk 1:2560 1:10,240
6 21/F 6 wk 1:80 1:1,280
7 46/M 5 d 1:2,560 1:80
8 31/F 1 wk 1:10,240 1:160
9 32/F 2 wk 1:81,900 1:327,680
10 51/F 4 and 8 wk 1:320 and 1:160 1:2,560 and 1:640
11 20/F 6 wk 1:320 1:2,560
12 47/M 8 wk 1:160 1:320
13 32/M 16 wk 1:20 1:160
14 43/F 8 wk 1:320 1:2,560
15 53/M 3 d, 2 wk, and 9 wk 1:320, 1:10,240, and 1:640 1:20, 1:1,280, and 1:320
16 49/F 6 wk 1:1,280 1:2,560

*By indirect immunofluorescence testing; reference value <1:20 (2).

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References
  1. Harley  D, Sleigh  A, Ritchie  S. Ross River virus transmission, infection, and disease: a cross-disciplinary review. Clin Microbiol Rev. 2001;14:909–32. DOIPubMedGoogle Scholar
  2. Tappe  D, Schmidt-Chanasit  J, Ries  A, Ziegler  U, Müller  A, Stich  A. Ross River virus infection in a traveller returning from northern Australia. Med Microbiol Immunol (Berl). 2009;198:271–3. DOIPubMedGoogle Scholar
  3. Soden  M, Vasudevan  H, Roberts  B, Coelen  R, Hamlin  G, Vasudevan  S, et al. Detection of viral ribonucleic acid and histologic analysis of inflamed synovium in Ross River virus infection. Arthritis Rheum. 2000;43:365–9. DOIPubMedGoogle Scholar
  4. Suhrbier  A, La Linn  M. Clinical and pathologic aspects of arthritis due to Ross River virus and other alphaviruses. Curr Opin Rheumatol. 2004;16:374–9. DOIPubMedGoogle Scholar
  5. Lidbury  BA, Rulli  NE, Suhrbier  A, Smith  PN, McColl  SR, Cunningham  AL, et al. Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus. J Infect Dis. 2008;197:1585–93. DOIPubMedGoogle Scholar
  6. Ng  LF, Chow  A, Sun  YJ, Kwek  DJ, Lim  PL, Dimatatac  F, et al. IL-1β, IL-6, and RANTES as biomarkers of chikungunya severity. PLoS One. 2009;4:e4261. DOIPubMedGoogle Scholar
  7. Tappe  D, Pérez-Girón  JV, Just-Nübling  G, Schuster  G, Gómez-Medina  S, Günther  S, et al. Sustained elevated cytokine levels during recovery phase of Mayaro virus infection. Emerg Infect Dis. 2016;22:750–2. DOIPubMedGoogle Scholar
  8. Chen  W, Foo  SS, Sims  NA, Herrero  LJ, Walsh  NC, Mahalingam  S. Arthritogenic alphaviruses: new insights into arthritis and bone pathology. Trends Microbiol. 2015;23:35–43. DOIPubMedGoogle Scholar
  9. Chen  W, Foo  SS, Rulli  NE, Taylor  A, Sheng  KC, Herrero  LJ, et al. Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss. Proc Natl Acad Sci U S A. 2014;111:6040–5. DOIPubMedGoogle Scholar
  10. Chow  A, Her  Z, Ong  EK, Chen  JM, Dimatatac  F, Kwek  DJ, et al. Persistent arthralgia induced by chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis. 2011;203:149–57. DOIPubMedGoogle Scholar

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1Deceased.

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