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Volume 23, Number 5—May 2017
Dispatch

Exposure Risk for Infection and Lack of Human-to-Human Transmission of Mycobacterium ulcerans Disease, Australia

Daniel P. O’BrienComments to Author , James W. Wynne, Andrew H. Buultjens, Wojtek P. Michalski, Timothy P. Stinear, N. Deborah Friedman, Andrew Hughes, and Eugene Athan
Author affiliations: Médecins Sans Frontières, London, UK (D.P. O’Brien); University of Melbourne, Melbourne, Victoria, Australia (D.P. O’Brien, A.H. Buultjens, T.P. Stinear); Barwon Health, Geelong, Victoria, Australia (D.P. O’Brien, N.D. Friedman, A. Hughes, E. Athan); Commonwealth Scientific and Industrial Research Organisation, Geelong (J.W. Wynne, W.P. Michalski); Deakin University School of Medicine, Geelong (E. Athan)

Main Article

Table 2

Description of 8 single-nucleotide polymorphisms specific to >1 of 6 family cluster isolates of Mycobacterium ulcerans disease, Bellarine Peninsula, Victoria, Australia, 1998–2016*

Position Loci Protein Substitution Amino acid change Isolate Coverage statistics
398430 Intergenic – G/A – mu179 T: 0, A: 35, G: 0, C: 1
398430 Intergenic – G/A – mu180 T: 0, A: 67, G: 0, C: 0
398430 Intergenic – G/A – mu248 T: 0, A: 100, G: 0, C: 1
398430 Intergenic – G/A – mu294 T: 0, A: 75, G: 0, C: 0
398430 Intergenic – G/A – mu308 T: 0, A: 58, G: 0, C: 0
1758272 MUL_1618 Membrane protein C/T Synonymous mu248 T: 91, A: 1, G: 0, C: 0
2153447 MUL_1947 Thiamine pyrophosphate A/G Lys→Arg mu294 T: 0, A: 1, G: 58, C: 0
2153447 MUL_1947 Thiamine pyrophosphate A/G Lys→Arg mu308 T: 0, A: 0, G: 40, C: 0
2462577 MUL_2205 Hypothetical protein T/C Asp→Gly mu179 T: 1, A: 1, G: 0, C: 47
4359638 MUL_3902 Membrane protein C/A Ala→Ser mu180 T: 0, A: 60, G: 1, C: 0
4359638 MUL_3902 Membrane protein C/A Ala→Ser mu248 T: 0, A: 108, G: 0, C: 1
5189291 Intergenic – G/T – mu248 T: 76, A: 0, G: 4, C: 0
5354966 MUL_4830 Putative GTPase T/C Synonymous mu180 T: 2, A: 0, G: 1, C: 18
5354966 MUL_4830 Putative GTPase T/C Synonymous mu248 T: 0, A: 0, G: 0, C: 20
5577431 MUL_5032 Immunogenic protein mbt64 A/G Synonymous mu394 T: 0, A: 0, G: 28, C: 0

*A total of 4,918 core single-nucleotide polymorphisms were identified for all 6 isolates compared with the African Agy99 reference genome. –, not applicable (mutations were not within a coding region).

Main Article

Page created: April 14, 2017
Page updated: April 14, 2017
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