Volume 23, Number 5—May 2017
Dispatch
Estimated Incubation Period for Zika Virus Disease
Table
Demographics, travel data, and laboratory testing results for Zika virus disease patients, United States, January 1, 2015, through June 23, 2016
Patient characteristic | All cases, no. (%), n = 197* | Confirmed cases, no. (%), n = 79† |
---|---|---|
Age, y | ||
0–19 | 19 (10) | 10 (13) |
20–39 | 71 (36) | 29 (37) |
40–59 | 79 (40) | 32 (40) |
>60 | 27 (14) | 7 (9) |
Unknown |
1 (<1) |
1 (1) |
Sex | ||
M | 77 (39) | 26 (33) |
F | 119 (60) | 52 (66) |
Unknown |
1 (1) |
1 (1) |
Pregnant | ||
Yes | 11 (6) | 2 (3) |
No | 161 (82) | 60 (76) |
Unknown |
25 (13) |
17 (22) |
Travel duration, d | ||
<7 | 24 (12) | 15 (19) |
7–13 | 88 (45) | 64 (81) |
14–20 | 31 (16) | 0 |
21–27 | 12 (6) | 0 |
≥28 | 42 (21) | 0 |
*Persons with Zika virus–like symptoms and positive results for Zika virus RNA by real-time reverse transcription PCR or positive results for Zika or dengue virus IgM and Zika virus plaque reduction neutralization test (PRNT) results >10 and Zika virus titer >4-fold higher than dengue virus titer.
†Persons who traveled <2 weeks, experienced Zika virus–like symptoms, and had positive Zika virus RNA results by real-time reverse transcription PCR or positive Zika or dengue virus IgM results and PRNT >10 and dengue PRNT <10.
References
- Brooks JT, Friedman A, Kachur RE, LaFlam M, Peters PJ, Jamieson DJ. Update: interim guidance for prevention of sexual transmission of Zika virus—United States, July 2016. MMWR Morb Mortal Wkly Rep. 2016;65:745–7. DOIPubMedGoogle Scholar
- Zanluca C, Melo VCAD, Mosimann ALP, Santos GIVD, Santos CNDD, Luz K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110:569–72. DOIPubMedGoogle Scholar
- Pan American Health Organization, World Health Organization. Zika epidemiological update—June 30, 2016 [cited 2016 Aug 15]. http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&itemid=270&gid=35262&lang=en
- Rabe IB, Staples JE, Villanueva J, Hummel KB, Johnson JA, Rose L, et al.; MTS. MTS. Interim guidance for interpretation of Zika virus antibody test results. MMWR Morb Mortal Wkly Rep. 2016;65:543–6. DOIPubMedGoogle Scholar
- Reich NG, Lessler J, Cummings DAT, Brookmeyer R. Estimating incubation period distributions with coarse data. Stat Med. 2009;28:2769–84. DOIPubMedGoogle Scholar
- Johansson MA, Arana-Vizcarrondo N, Biggerstaff BJ, Staples JE. Incubation periods of Yellow fever virus. Am J Trop Med Hyg. 2010;83:183–8. DOIPubMedGoogle Scholar
- Meaney-Delman D, Oduyebo T, Polen KN, White JL, Bingham AM, Slavinski SA, et al.; U.S. Zika Pregnancy Registry Prolonged Viremia Working Group. Prolonged detection of Zika virus RNA in pregnant women. Obstet Gynecol. 2016;128:724–30. DOIPubMedGoogle Scholar