Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 5—May 2017
Dispatch

Estimated Incubation Period for Zika Virus Disease

Elisabeth R. Krow-Lucal, Brad J. Biggerstaff, and J. Erin StaplesComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.R. Krow-Lucal); Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (E.R. Krow-Lucal, B.J. Biggerstaff, J.E. Staples)

Main Article

Table

Demographics, travel data, and laboratory testing results for Zika virus disease patients, United States, January 1, 2015, through June 23, 2016

Patient characteristic All cases, no. (%), n = 197* Confirmed cases, no. (%), n = 79†
Age, y
0–19 19 (10) 10 (13)
20–39 71 (36) 29 (37)
40–59 79 (40) 32 (40)
>60 27 (14) 7 (9)
Unknown
 1 (<1)
 1 (1)
Sex
M 77 (39) 26 (33)
F 119 (60) 52 (66)
Unknown
 1 (1)
 1 (1)
Pregnant
Yes 11 (6) 2 (3)
No 161 (82) 60 (76)
Unknown
 25 (13)
 17 (22)
Travel duration, d
<7 24 (12) 15 (19)
7–13 88 (45) 64 (81)
14–20 31 (16) 0
21–27 12 (6) 0
≥28 42 (21) 0

*Persons with Zika virus–like symptoms and positive results for Zika virus RNA by real-time reverse transcription PCR or positive results for Zika or dengue virus IgM and Zika virus plaque reduction neutralization test (PRNT) results >10 and Zika virus titer >4-fold higher than dengue virus titer.
†Persons who traveled <2 weeks, experienced Zika virus–like symptoms, and had positive Zika virus RNA results by real-time reverse transcription PCR or positive Zika or dengue virus IgM results and PRNT >10 and dengue PRNT <10.

Main Article

References
  1. Staples  JE, Dziuban  EJ, Fischer  M, Cragan  JD, Rasmussen  SA, Cannon  MJ, et al. Interim guidelines for the evaluation and testing of infants with possible congenital Zika virus infection—United States, 2016. MMWR Morb Mortal Wkly Rep. 2016;65:63–7. DOIPubMedGoogle Scholar
  2. Brooks  JT, Friedman  A, Kachur  RE, LaFlam  M, Peters  PJ, Jamieson  DJ. Update: interim guidance for prevention of sexual transmission of Zika virus—United States, July 2016. MMWR Morb Mortal Wkly Rep. 2016;65:745–7. DOIPubMedGoogle Scholar
  3. Centers for Disease Control and Prevention. Zika virus: transmission & risks [cited 2016 Sep 23]. http://www.cdc.gov/zika/transmission/
  4. Zanluca  C, Melo  VCAD, Mosimann  ALP, Santos  GIVD, Santos  CNDD, Luz  K. First report of autochthonous transmission of Zika virus in Brazil. Mem Inst Oswaldo Cruz. 2015;110:569–72. DOIPubMedGoogle Scholar
  5. Pan American Health Organization, World Health Organization. Zika epidemiological update—June 30, 2016 [cited 2016 Aug 15]. http://www.paho.org/hq/index.php?option=com_docman&task=doc_view&itemid=270&gid=35262&lang=en
  6. Lanciotti  RS, Kosoy  OL, Laven  JJ, Velez  JO, Lambert  AJ, Johnson  AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis. 2008;14:1232–9. DOIPubMedGoogle Scholar
  7. Rabe  IB, Staples  JE, Villanueva  J, Hummel  KB, Johnson  JA, Rose  L, et al.; MTS. MTS. Interim guidance for interpretation of Zika virus antibody test results. MMWR Morb Mortal Wkly Rep. 2016;65:543–6. DOIPubMedGoogle Scholar
  8. Reich  NG, Lessler  J, Cummings  DAT, Brookmeyer  R. Estimating incubation period distributions with coarse data. Stat Med. 2009;28:2769–84. DOIPubMedGoogle Scholar
  9. Chan  M, Johansson  MA. The incubation periods of Dengue viruses. PLoS One. 2012;7:e50972. DOIPubMedGoogle Scholar
  10. Centers for Disease Control and Prevention. West Nile virus infection in organ donor and transplant recipients—Georgia and Florida. JAMA. 2002;288:1465–6. DOIGoogle Scholar
  11. Johansson  MA, Arana-Vizcarrondo  N, Biggerstaff  BJ, Staples  JE. Incubation periods of Yellow fever virus. Am J Trop Med Hyg. 2010;83:183–8. DOIPubMedGoogle Scholar
  12. Rudolph  KE, Lessler  J, Moloney  RM, Kmush  B, Cummings  DAT. Incubation periods of mosquito-borne viral infections: a systematic review. Am J Trop Med Hyg. 2014;90:882–91. DOIPubMedGoogle Scholar
  13. Lessler  JT, Ott  CT, Carcelen  AC, Konikoff  JM, Williamson  J, Bi  Q, et al. Times to key events in the course of Zika infection and their implications: a systematic review and pooled analysis [cited 2016 Aug 15]. http://www.who.int/bulletin/online_first/BLT.16.174540.pdf
  14. Recognizing, managing, and reporting Zika virus infections in travelers returning from Central America, South America, the Caribbean, and Mexico [cited 2016 Aug 15]. http://emergency.cdc.gov/han/han00385.asp
  15. Meaney-Delman  D, Oduyebo  T, Polen  KN, White  JL, Bingham  AM, Slavinski  SA, et al.; U.S. Zika Pregnancy Registry Prolonged Viremia Working Group. Prolonged detection of Zika virus RNA in pregnant women. Obstet Gynecol. 2016;128:724–30. DOIPubMedGoogle Scholar

Main Article

Page created: April 14, 2017
Page updated: April 14, 2017
Page reviewed: April 14, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external