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Volume 23, Number 5—May 2017
Dispatch

Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Gerald L. MurrayComments to Author , Catriona S. Bradshaw, Melanie Bissessor, Jennifer A. Danielewski, Suzanne M. Garland, Jørgen S. Jensen, Christopher K. Fairley, and Sepehr N. Tabrizi
Author affiliations: Monash University, Clayton, Victoria, Australia (G.L. Murray); Murdoch Childrens Research Institute, Parkville, Victoria, Australia (G.L. Murray, J. Danielewski, S.M. Garland, S.N. Tabrizi); Royal Women’s Hospital, Parkville (G.L. Murray, S.M. Garland, S.N. Tabrizi); Alfred Health, Carlton, Victoria, Australia (C.S. Bradshaw, M. Bissessor, C.K. Fairley); University of Melbourne, Parkville (C.S. Bradshaw, S.M. Garland, S.N. Tabrizi); Monash University, Melbourne, Victoria, Australia (C.S. Bradshaw, C.K. Fairley); Statens Serum Institut, Copenhagen, Denmark (J.S. Jensen)

Main Article

Table 1

Pretreatment gyrA and parC SNPs detected according to moxifloxacin treatment from 140 samples collected from patients with Mycoplasma genitalium infection, Melbourne, Australia, July 2012 through June 2013*

Gene, SNP† Amino acid change Moxifloxacin failure, no. (%), n = 6‡ Moxifloxacin success, no. (%), n = 48 Not treated with moxifloxacin, no. (%), n = 86 Total prevalence, no. (%), n = 140
gyrA
A229G§ K77E – – 1 (1.2) 1 (0.71)
G240A§ Silent (R80) – – 1 (1.2) 1 (0.71)
G285A M95I 2 (33)¶ 2 (4.2)¶ – 4 (2.9)
G295A§ D99N 1 (17)¶ – – 1 (0.71)
G295T§ D99Y 1 (17)¶ – – 1 (0.71)
A296G§
 D99G
 1 (17)
 –
 –
 1 (0.71)
parC
C184T§ P62S – – 13 (15) 13 (9.3)
C234T Silent (H78) – 6 (12.5) 10 (12) 17 (12)
A247C S83R 2 (33) – – 2 (1.4)
G248T S83I 4 (67) 3 (6.3) 7 (8.1) 14 (10)
G259A D87N – 1 (2.1) 2 (2.3) 3 (2.1)
T269A§ I90N – – 1 (1.2) 1 (0.71)
C324T§
 Silent (N108)
 –
 –
 1 (1.2)
 1 (0.71)
No change – – 38 (79) 60 (70) 98 (68.5)

*SNP, single-nucleotide polymorphism; –, mutation absent.
†The M. genitalium G37 genome sequence (NC_000908) was the reference sequence.
‡All corresponding postmoxifloxacin treatment-failure samples contained the same SNP profiles. Multiple SNPs were detected in some samples.
§Sequence variations not previously described in M. genitalium.
¶A mutation was combined with an S83 change.

Main Article

Page created: April 17, 2017
Page updated: April 17, 2017
Page reviewed: April 17, 2017
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