Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 5—May 2017

Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium

Gerald L. MurrayComments to Author , Catriona S. Bradshaw, Melanie Bissessor, Jennifer A. Danielewski, Suzanne M. Garland, Jørgen S. Jensen, Christopher K. Fairley, and Sepehr N. Tabrizi
Author affiliations: Monash University, Clayton, Victoria, Australia (G.L. Murray); Murdoch Childrens Research Institute, Parkville, Victoria, Australia (G.L. Murray, J. Danielewski, S.M. Garland, S.N. Tabrizi); Royal Women’s Hospital, Parkville (G.L. Murray, S.M. Garland, S.N. Tabrizi); Alfred Health, Carlton, Victoria, Australia (C.S. Bradshaw, M. Bissessor, C.K. Fairley); University of Melbourne, Parkville (C.S. Bradshaw, S.M. Garland, S.N. Tabrizi); Monash University, Melbourne, Victoria, Australia (C.S. Bradshaw, C.K. Fairley); Statens Serum Institut, Copenhagen, Denmark (J.S. Jensen)

Main Article

Table 2

Samples containing changes in key amino acids of ParC and GyrA from 140 patients with Mycoplasma genitalium infection, Melbourne, Australia, July 2012 through June 2013*

Patient no./sex Sample Log10 load, GEQ† Treatment (moxifloxacin) outcome SNPs in parC
SNPs in gyrA
1/F Cervical swab 4.73 Failure + +
2/M Urine 2.94 Failure + +
3/F Anal swab 2.15 Failure + +
4/M Urine 3.80 Failure + +
5/M Urethral swab 5.10 Failure + +
6/M Urine 4.66 Failure +
7/F Cervical swab 1.82 Success + +
8/M Urine 2.47 Success + +
9/M Urine 1.82 Success +
10/M Urine 4.07 Success +
11/F Urine 2.47 NT +
12/M Urine 3.46 NT +
13/M Urine 4.51 NT +
14/M Urine 3.51 NT +
15/M Urine 2.25 NT +
16/M Urine 1.11 NT +
17/F Urine 1.94 NT +
18/M Urine 2.50 NT +
19/F Cervical/swab 3.08 NT +

*Dataset includes all failed treatments for moxifloxacin. GEQ, genome equivalent; NT, not treated with moxifloxacin because azithromycin treatment was successful; SNP, single-nucleotide polymorphism; +, sequencing of sample successful and SNP present; –, SNP absent.
†The log10 loads of M. genitalium were calculated per swab or 1 mL of urine. For all 155 patients in the parent cohort, loads varied from 0.84 to 6.17 (median 3.36).

Main Article

Page created: April 17, 2017
Page updated: April 17, 2017
Page reviewed: April 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.