Volume 23, Number 5—May 2017
Dispatch
Increasing Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium
Gerald L. Murray
, Catriona S. Bradshaw, Melanie Bissessor, Jennifer A. Danielewski, Suzanne M. Garland, Jørgen S. Jensen, Christopher K. Fairley, and Sepehr N. Tabrizi
, Catriona S. Bradshaw, Melanie Bissessor, Jennifer A. Danielewski, Suzanne M. Garland, Jørgen S. Jensen, Christopher K. Fairley, and Sepehr N. Tabrizi
Table 2
Samples containing changes in key amino acids of ParC and GyrA from 140 patients with Mycoplasma genitalium infection, Melbourne, Australia, July 2012 through June 2013*
| Patient no./sex | Sample | Log10 load, GEQ† | Treatment (moxifloxacin) outcome | SNPs in parC |
SNPs in gyrA |
||||||
| A247C
S83R |
G248T
S83I |
G259A
D87N |
G285A
M95I |
G295A
D99N |
G295T
D99Y |
A296G
D99G |
|||||
| 1/F | Cervical swab | 4.73 | Failure | – | + | – | + | – | – | – | |
| 2/M | Urine | 2.94 | Failure | – | + | – | + | – | – | – | |
| 3/F | Anal swab | 2.15 | Failure | – | + | – | – | + | – | – | |
| 4/M | Urine | 3.80 | Failure | – | + | – | – | – | – | + | |
| 5/M | Urethral swab | 5.10 | Failure | + | – | – | – | – | + | – | |
| 6/M | Urine | 4.66 | Failure | + | – | – | – | – | – | – | |
| 7/F | Cervical swab | 1.82 | Success | – | + | – | + | – | – | – | |
| 8/M | Urine | 2.47 | Success | – | + | – | + | – | – | – | |
| 9/M | Urine | 1.82 | Success | – | + | – | – | – | – | – | |
| 10/M | Urine | 4.07 | Success | – | – | + | – | – | – | – | |
| 11/F | Urine | 2.47 | NT | – | + | – | – | – | – | – | |
| 12/M | Urine | 3.46 | NT | – | + | – | – | – | – | – | |
| 13/M | Urine | 4.51 | NT | – | + | – | – | – | – | – | |
| 14/M | Urine | 3.51 | NT | – | + | – | – | – | – | – | |
| 15/M | Urine | 2.25 | NT | – | + | – | – | – | – | – | |
| 16/M | Urine | 1.11 | NT | – | + | – | – | – | – | – | |
| 17/F | Urine | 1.94 | NT | – | + | – | – | – | – | – | |
| 18/M | Urine | 2.50 | NT | – | – | + | – | – | – | – | |
| 19/F | Cervical/swab | 3.08 | NT | – | – | + | – | – | – | – | |
*Dataset includes all failed treatments for moxifloxacin. GEQ, genome equivalent; NT, not treated with moxifloxacin because azithromycin treatment was successful; SNP, single-nucleotide polymorphism; +, sequencing of sample successful and SNP present; –, SNP absent.
†The log10 loads of M. genitalium were calculated per swab or 1 mL of urine. For all 155 patients in the parent cohort, loads varied from 0.84 to 6.17 (median 3.36).
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