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Volume 23, Number 5—May 2017

Dispatch

Reassortant Clade 2.3.4.4 Avian Influenza A(H5N6) Virus in a Wild Mandarin Duck, South Korea, 2016

Jung-Hoon Kwon1, Dong-Hun Lee1, David E. Swayne, Jin-Yong Noh, Seong-Su Yuk, Tseren-Ochir Erdene-Ochir, Woo-Tack Hong, Jei-Hyun Jeong, Sol Jeong, Gyeong-Bin Gwon, Seok Lee, and Chang-Seon SongComments to Author 
Author affiliations: Konkuk University, Seoul, South Korea (J.-H. Kwon, J.-Y. Noh, S.-S. Yuk, T.-O. Erdene-Ochir, W.-T. Hong, J.-H. Jeong, S. Jeong, G.-B. Gwon, C.-S. Song); US Department of Agriculture, Athens, Georgia, USA (D.-H. Lee, D.E. Swayne); Korea Institute of Science and Technology, Seoul (S. Lee)

Main Article

Table 2

Amino acid analysis of avian influenza A(H5N6) virus from a wild mandarin duck, South Korea, 2016, and reference strains of clade 2.3.4.4 H5N6 subtype virus*

Group, strain NA del,§
59–69 NS¶
HA (H5 numbering)†
PB2‡
42 80–84 del PDZ
123 126 129 133 156 222 224 591 627 701
South Korea H5N6 subtype and closely related avian isolates
A/Mandarin_duck/Korea/K16-187-3/
 2016 P E Del S A Q G Q E D Yes S Yes ESEV
A/great_egret/Hong_Kong/00032/2016 P E Del A A Q G Q ? ? Yes ? ? No
A/environment/Guangdong/GZ693/
 2015
P
E
L
A
A
Q
G

Q
E
D
No
S
No
ESEV
C, human isolates
A/Shenzhen/1/2016 P Del S A A Q G Q K D Yes S No No
A/_Guangdong_/ZQ874/2015H5N6 P E L A A Q G Q E D Yes S Del ESEV
A/_Guangdong_/SZ872/2015H5N6 P Del S A A Q G Q E D Yes S No No
A/Shenzhen/1/2015 P Del S A A Q G Q E D Yes S No No
A/Yunnan/14563/2015 P Del S A A Q G Q K D Yes S No No
A/Yunnan/14564/2015 P Del S A A Q G Q K D Yes S No No
A/Yunnan/0127/2015 P Del S A A Q G Q K D Yes S Yes No
A/Guangzhou/39715/2014 P E L A T Q G Q K D Yes S Yes ESEV
A/Changsha/1/2014
P
Del
S
A
A
Q
G

Q
E
D
Yes
S
Yes
ESEV
D, human isolate
A/Sichuan/26221/2014
T
E
L
A
A
Q
G

Q
E
N
No
S
Yes
ESEV
C, mammalian isolates
A/swine/Guangdong/1/2014 P E L A A Q G Q E D Yes S Yes EPEV
A/swine/Guangdong/2/2014 P E L A A Q G Q E D Yes S Yes EPEV
A/feline/Guangdong/1/2015 P E L A A Q G Q E D Yes S Yes ESEV
A/feline/Guangdong/2/2015 P E L A A Q G Q E D Yes S Yes ESEV

*Del, deletion; HA, hemagglutinin; NA, neuraminidase; NS, nonstructural protein; PB2, polymerase basic 2; PDZ, PDZ binding motif.
†S123P, S133A, T156A, Q222L, and G224S mutations in HA have been associated with increased binding to human-like receptor (α-2–6 sialic acid).
‡Q591K, E627K, and D701N mutations have been associated with improved replication of avian influenza virus in mammals.
§NA stalk deletion has been associated with enhanced pathogenicity in mice.
¶42S, 80–84 deletion, and ESEV PDZ binding motif have been associated with increased virulence in mice.

Main Article

1These authors contributed equally to this article.

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