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Volume 23, Number 5—May 2017
Research Letter

mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France

Yvan CasparComments to Author , Mylène Maillet, Patricia Pavese, Gilles Francony, Jean-Paul Brion, Marie-Reine Mallaret, Richard Bonnet, Frédéric Robin, Racha Beyrouthy, and Max Maurin
Author affiliations: Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France (Y. Caspar, M. Maillet, P. Pavese, G. Francony, J.-P. Brion, M.-R. Mallaret, M. Maurin); University Grenoble-Alpes, CNRS, Grenoble; Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France (R. Bonnet, F. Robin, R. Beyrouthy); Centre National de Référence de la Résistance aux Antibiotiques, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Université Clermont Auvergne, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Institut National de la Recherche Agronomique, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy)

Main Article

Table

Resistance genes identified by whole-genome sequencing of an ESBL-producing mcr-1−positive Klebsiella pneumoniae strain isolated from a 38-year-old man, France*

Resistance gene Target antimicrobial drug
mcr-1 and inactivation of mgrB by IS5 insertion Colistin
blaSHV-106 β-lactams
aac(3)-IId and aadA16-like Aminoglycoside
aac(6′)Ib-cr Quinolone and aminoglycoside
fosA5 Fosfomycin
sulI and folP Sulfonamide
dfrA27 Trimethoprim
tetD Tetracycline

*ESBL, extended-spectrum β-lactamase.

Main Article

Page created: April 17, 2017
Page updated: April 17, 2017
Page reviewed: April 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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