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Volume 23, Number 5—May 2017

Research Letter

mcr-1 Colistin Resistance in ESBL-Producing Klebsiella pneumoniae, France

Yvan CasparComments to Author , Mylène Maillet, Patricia Pavese, Gilles Francony, Jean-Paul Brion, Marie-Reine Mallaret, Richard Bonnet, Frédéric Robin, Racha Beyrouthy, and Max Maurin
Author affiliations: Centre Hospitalier Universitaire Grenoble-Alpes, Grenoble, France (Y. Caspar, M. Maillet, P. Pavese, G. Francony, J.-P. Brion, M.-R. Mallaret, M. Maurin); University Grenoble-Alpes, CNRS, Grenoble; Centre Hospitalier Universitaire Clermont-Ferrand, Clermont-Ferrand, France (R. Bonnet, F. Robin, R. Beyrouthy); Centre National de Référence de la Résistance aux Antibiotiques, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Université Clermont Auvergne, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Institut National de la Santé et de la Recherche Médicale, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy); Institut National de la Recherche Agronomique, Clermont-Ferrand (R. Bonnet, F. Robin, R. Beyrouthy)

Main Article

Table

Resistance genes identified by whole-genome sequencing of an ESBL-producing mcr-1−positive Klebsiella pneumoniae strain isolated from a 38-year-old man, France*

Resistance gene Target antimicrobial drug
mcr-1 and inactivation of mgrB by IS5 insertion Colistin
blaSHV-106 β-lactams
aac(3)-IId and aadA16-like Aminoglycoside
aac(6′)Ib-cr Quinolone and aminoglycoside
fosA5 Fosfomycin
sulI and folP Sulfonamide
dfrA27 Trimethoprim
tetD Tetracycline

*ESBL, extended-spectrum β-lactamase.

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