Volume 23, Number 6—June 2017
Dispatch
Domestic Pig Unlikely Reservoir for MERS-CoV
Emmie de Wit, Friederike Feldmann, Eva Horne, Cynthia Martellaro, Elaine Haddock, Trenton Bushmaker, Kyle Rosenke, Atsushi Okumura, Rebecca Rosenke, Greg Saturday, Dana Scott, and Heinz Feldmann
Table
Comparison of the amino acid residues shown to be essential in binding of Middle East respiratory syndrome coronavirus spike protein to DPP4 of human, dromedary camel, and domestic pig*
| Species |
DPP4, aa position | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 229 |
267 |
286 |
288 |
291 |
294 |
295 |
298 |
317 |
322 |
336 |
341 |
344 |
346 |
|
| Human† |
N |
K |
Q |
T |
A |
L |
I |
H |
R |
Y |
R |
V |
Q |
I |
| Dromedary camel‡ |
– |
– |
– |
V |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
| Domestic pig§ |
– |
– |
– |
V |
– |
– |
– |
– |
– |
– |
– |
– |
– |
– |
| Mouse¶ | – | – | – | P | – | A | R | – | – | – | T | S | – | V |
*DPP4, dipeptidyl peptidase 4; –, no change from human DPP4.
†GenBank accession no. AB451339.
‡GenBank accession no. KF574263.
§GenBank accession no. NM214257.
¶Taken from previous publication (7).
Page created: May 16, 2017
Page updated: May 16, 2017
Page reviewed: May 16, 2017
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