Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 7—July 2017

Environmental Factors as Key Determinants for Visceral Leishmaniasis in Solid Organ Transplant Recipients, Madrid, Spain

Nerea Carrasco-AntónComments to Author , Francisco López-Medrano, Mario Fernández-Ruiz, Eugenia Carrillo, Javier Moreno, Ana García-Reyne, Ana Pérez-Ayala, María Luisa Rodríguez-Ferrero, Carlos Lumbreras, Rafael San-Juan, Jorge Alvar, and José María Aguado
Author affiliations: University Hospital 12 de Octubre of Complutense University of Madrid, Madrid, Spain (N. Carrasco-Antón, F. López-Medrano, M. Fernández-Ruiz, A. García-Reyne, A. Pérez-Ayala, C. Lumbreras, R. San-Juan, J.M. Aguado); Instituto de Salud Carlos III, Madrid (E. Carrillo, J. Moreno); Hospital General Universitario Gregorio Marañón, Madrid (M.L. Rodriguez-Ferrero); Drugs for Neglected Diseases Initiative, Geneva, Switzerland (J. Alvar)

Main Article

Table 2

Disease characteristics, demographics, clinical characteristics, therapy, and outcomes of 7 solid organ transplant recipients with VL, Madrid, Spain, January 1, 2005–January 1, 2013*

Characteristics Patient no.
1 2 3 4 5 6 7
Sex M M M M M F M
Race Black Black White White White White White
Linear distance from patient’s residence to park, m 794 399 261 1,240 985 233 358
Age at transplant, y 35 34 76 55 68 49 52
Type of SOT Kidney Kidney Kidney Kidney Kidney Heart Kidney
Donor Leishmania spp. serostatus Negative NP Negative NP Negative Negative Negative
Pretransplant recipient Leishmania spp. serostatus NP NP Negative Positive Negative Negative Negative
Date of transplant 2011 Feb 11 2010 Jan 22 2010 Mar 10 2010 Jul 7 2009 Dec 29 2010 Sep 5 2010 Apr 15
Interval from transplant to VL diagnosis, y 1.17 2.44 0.25 1.4 0.17 1.81 2.21
Fever at admission Yes Yes No Yes Yes Yes Yes
Pancytopenia Yes Yes Yes Yes Yes Yes Yes
Splenomegaly Yes Yes Yes Yes Yes Yes Yes
Serologic testing results for Leishmania spp. Positive Negative Negative Positive Negative Positive Negative
Presence of amastigote forms in bone marrow sample Positive Positive Positive Positive Positive Positive Positive
PCR assay results of bone marrow sample NP NP NP Negative NP NP NP
NNN culture results of bone marrow sample Positive NP Positive Negative Negative Positive Negative
Initial therapy L-AmB L-AmB L-AmB L-AmB L-AmB L-AmB L-AmB
Relapse Yes No Yes Yes No No No
Outcome Renal failure Graft loss Cured Graft loss Cured Cured Cured

*L-AmB, liposomal amphotericin B; NNN, Novy-McNeal-Nicolle; NP, not performed; SOT, solid organ transplant; VL, visceral leishmaniasis.

Main Article

Page created: June 19, 2017
Page updated: June 19, 2017
Page reviewed: June 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.