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Volume 23, Number 8—August 2017
Research

Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine

Gavin G. Rutledge1, Ian Marr1, G. Khai Lin Huang, Sarah Auburn, Jutta Marfurt, Mandy Sanders, Nicholas J. White, Matthew Berriman, Chris I. Newbold, Nicholas M. Anstey, Thomas D. OttoComments to Author , and Ric N. PriceComments to Author 
Author affiliations: Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom (G.G. Rutledge, M. Sanders, M. Berriman, C.I. Newbold, T.D. Otto); Royal Darwin Hospital, Casuarina, Northern Territory, Australia (I. Marr, G.K.L. Huang, N.M. Anstey, R.N. Price); Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia (S. Auburn, J. Marfurt, N.M. Anstey, R.N. Price); Mahidol University Faculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand (N.J. White); University of Oxford Centre for Tropical Medicine and Global Health, Oxford, United Kingdom (N.J. White, R.N. Price); University of Oxford Weatherall Institute of Molecular Medicine, Oxford (C.I. Newbold)

Main Article

Figure 1

Timeline of the clinical case of a patient with Plasmodium malariae infection diagnosed and treated at Royal Darwin Hospital, Darwin, Northern Territory, Australia, March–April 2015, showing the timing (A), treatment (B), parasite’s genotype as inferred from whole-genome sequencing (C), clinical presentation (D), and location (E). The rounded arrow indicates the recrudescence of the minor haplotype 2 in the initial infection to dominate monoclonally in the second infection. AL, artemether/lumefa

Figure 1. Timeline of the clinical case of a patient with Plasmodium malariae infection diagnosed and treated at Royal Darwin Hospital, Darwin, Northern Territory, Australia, March–April 2015, showing the timing (A), treatment (B), parasite’s genotype as inferred from whole-genome sequencing (C), clinical presentation (D), and location (E). The rounded arrow indicates the recrudescence of the minor haplotype 2 in the initial infection to dominate monoclonally in the second infection. AL, artemether/lumefantrine; H1, haplotype 1; H2; haplotype 2; MP Ag, pan-malarial antigen; R1, reference haplotype.

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1These authors contributed equally to this article.

Page created: July 17, 2017
Page updated: July 17, 2017
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