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Volume 23, Number 9—September 2017

Research Letter

Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion

Allen Herbst1, Camilo Duque Velásquez1, Elizabeth Triscott, Judd M. Aiken, and Debbie McKenzieComments to Author 
Author affiliations: University of Alberta, Edmonton, Alberta, Canada

Main Article

Table

Results of CWD prion inoculation into rodents*

Recipient and CWD
inocula
No.
PrP-res+ Incubation period, d
Clinical
Subclinical
Mice
wt/wt 6 0 0 NA
S96/wt 6 0 0 NA
H95/wt 7 5 2 669, 671, 706, 706, 706
H95/S96 7 7 0 306, 593, 593, 593, 593, 673, 675
Elk 4 0 0 NA
Control
4
0
0
NA
Hamsters
wt/wt 8 3 5 652, 653, 653
S96/wt 8 1 4 634
H95/wt 8 1 6 652
H95/S96 8 0 1 NA
Elk 8 2 2 673, 719
Control 8 0 0 NA

*Mice infected with CWD prions were observed for up to 708 d; hamsters infected with white-tailed deer and elk CWD prions were observed for 659 and 726 d, respectively. Control mice and hamsters were inoculated with brain homogenates from CWD-negative wt/wt deer. CWD, chronic wasting disease; NA, not applicable; PrP-res+, positive for proteinase-K–resistant prion protein; wt, wild type.

Main Article

1These authors contributed equally to this article.

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