Volume 23, Number 9—September 2017
Research Letter
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion
Table
Results of CWD prion inoculation into rodents*
| Recipient and CWD
inocula |
No. |
PrP-res+ | Incubation period, d |
|
|---|---|---|---|---|
| Clinical |
Subclinical |
|||
| Mice | ||||
| wt/wt | 6 | 0 | 0 | NA |
| S96/wt | 6 | 0 | 0 | NA |
| H95/wt | 7 | 5 | 2 | 669, 671, 706, 706, 706 |
| H95/S96 | 7 | 7 | 0 | 306, 593, 593, 593, 593, 673, 675 |
| Elk | 4 | 0 | 0 | NA |
| Control |
4 |
0 |
0 |
NA |
| Hamsters | ||||
| wt/wt | 8 | 3 | 5 | 652, 653, 653 |
| S96/wt | 8 | 1 | 4 | 634 |
| H95/wt | 8 | 1 | 6 | 652 |
| H95/S96 | 8 | 0 | 1 | NA |
| Elk | 8 | 2 | 2 | 673, 719 |
| Control | 8 | 0 | 0 | NA |
*Mice infected with CWD prions were observed for up to 708 d; hamsters infected with white-tailed deer and elk CWD prions were observed for 659 and 726 d, respectively. Control mice and hamsters were inoculated with brain homogenates from CWD-negative wt/wt deer. CWD, chronic wasting disease; NA, not applicable; PrP-res+, positive for proteinase-K–resistant prion protein; wt, wild type.
1These authors contributed equally to this article.
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Page updated: August 17, 2017
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