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Volume 23, Number 9—September 2017


Influenza A(H3N2) Virus in Swine at Agricultural Fairs and Transmission to Humans, Michigan and Ohio, USA, 2016

Andrew S. BowmanComments to Author , Rasna R. Walia, Jacqueline M. Nolting, Amy L. Vincent, Mary Lea Killian, Michele M. Zentkovich, Joshua N. Lorbach, Sarah E. Lauterbach, Tavis K. Anderson, C. Todd Davis, Natosha Zanders, Joyce Jones, Yunho Jang, Brian Lynch, Marisela Rodriguez, Lenee Blanton, Stephen Lindstrom, David Wentworth, John Schiltz, James J. Averill, and Tony Forshey
Author affiliations: The Ohio State University, Columbus, Ohio, USA (A.S. Bowman, J.M. Nolting, M.M. Zentkovich, J.N. Lorbach, S.E. Lauterbach); US Department of Agriculture, Ames, Iowa, USA (R.R. Walia, A.L. Vincent, M.L. Killian, T.K. Anderson, J. Schiltz); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.T. Davis, N. Zanders, J. Jones, Y. Jang, B. Lynch, M.R. Rodriguez, L. Blanton, S.E. Lindstrom, D.E. Wentworth); Michigan Department of Agriculture and Rural Development, Lansing, Michigan, USA (J.J. Averill); Ohio Department of Agriculture, Reynoldsburg, Ohio (T. Forshey)

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Table 2

H3N2 genotypes identified in influenza A viruses detected in exhibition swine at agricultural fairs associated with 16 human variant H3N2 cases, Michigan and Ohio, USA, 2016*

Genotype PB2 PB1 PA HA NP NA M NS
H3 genotype 1, n = 2 trig trig trig Swine cluster IV-A trig 2002 pdm trig
Human-like H3, n = 11 trig trig trig Human-like H3 trig 2002 pdm Trig

*Genomic constellations of 13 influenza A virus isolates from swine are organized by the 8 gene segments of the influenza A virus genome with HA categorized as derived from the 2010–11 human seasonal H3N2 virus (human-like H3) or the established swine lineage H3N2 (cluster IV-A). The 6 internal gene segments (PB2, PB1, PA, NP, M, NS) are classified as originating from either the 1998 triple-reassortant internal gene (trig) or influenza A(H1N1)pdm09 (pdm). All NA genes were descendants of the 2002 N2 lineage common among North American swine (12). HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleoprotein; NS, nonstructural protein; PA, polymerase acidic; PB, polymerase basic.

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