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Volume 24, Number 1—January 2018
Letter

Investigation of Pneumonic Plague, Madagascar

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To the Editor: In an investigation of a pneumonic plague outbreak in Madagascar, Ramasindrazana et al. reported isolation of Yersinia pestis from 2 patients and seroconversion in 2 additional patients; these data indicated 4 (28.7%) of 14 diagnosed cases among described cases (1). The risk for overestimation of pneumonic plague contagion was illustrated by an outbreak in the Democratic Republic of the Congo that included cases of leptospirosis (2). In fact, thorough investigations in Uganda indicated that 2 index patients transmitted Y. pestis to only 1 caregiver each and none to 23 additional untreated close contacts (3). Another investigation in China showed that 3 index patients exposed 214 contacts during 3–13 days; all contacts were quarantined, and no secondary cases were reported (4). Transmission of Y. pestis by respiratory droplets requires face-to-face exposure with a coughing patient, as can occur during funerals by close contact with coughing persons who may have been exposed to the pathogen while visiting or attending the patient before he or she died. Therefore, the threat for plague epidemics fueled by pneumonic plague can be reduced by measures such as isolating patients and wearing a mask when exposure is likely (5).

We propose the hypothesis that only the transmission of Y. pestis by ectoparasites, such as lice and fleas, by close contact with infected humans can sustain outbreaks and epidemics. In plague-endemic regions, to support the appropriate management of patients and provide a rapid and accurate microbiological diagnosis, we recommend point-of-care laboratories, some of which are now operating in a few remote regions of Africa. In addition to direct diagnosis of disease in humans, direct detection of Y. pestis at the point-of-care in potential sources and vectors would facilitate understanding of how plague epidemics sustain.

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Michel DrancourtComments to Author  and Didier Raoult

Author affiliations: MEPHI, UMR, IRD, Aix-Marseille Université, Marseille, France

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References

  1. Ramasindrazana  B, Andrianaivoarimanana  V, Rakotondramanga  JM, Birdsell  DN, Ratsitorahina  M, Rajerison  M. Pneumonic plague transmission, Moramanga, Madagascar, 2015. Emerg Infect Dis. 2017;23:5214. DOIPubMed
  2. Bertherat  E, Mueller  MJ, Shako  JC, Picardeau  M. Discovery of a leptospirosis cluster amidst a pneumonic plague outbreak in a miners’ camp in the Democratic Republic of the Congo. Int J Environ Res Public Health. 2014;11:182433. DOIPubMed
  3. Begier  EM, Asiki  G, Anywaine  Z, Yockey  B, Schriefer  ME, Aleti  P, et al. Pneumonic plague cluster, Uganda, 2004. Emerg Infect Dis. 2006;12:4607. DOIPubMed
  4. Li  YF, Li  DB, Shao  HS, Li  HJ, Han  YD. Plague in China 2014-All sporadic case report of pneumonic plague. BMC Infect Dis. 2016;16:85. DOIPubMed
  5. Ratsitorahina  M, Chanteau  S, Rahalison  L, Ratsifasoamanana  L, Boisier  P. Epidemiological and diagnostic aspects of the outbreak of pneumonic plague in Madagascar. Lancet. 2000;355:1113. DOIPubMed

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DOI: 10.3201/eid2401.170760

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Table of Contents – Volume 24, Number 1—January 2018

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Michel Drancourt, MEPHI, UMR, Aix-Marsille Université, IRD, IHU Mediterranee Infection, 19-21 Blvd, Jean Moulin, 13005 Marseille, France

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Page created: December 19, 2017
Page updated: December 19, 2017
Page reviewed: December 19, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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