Volume 24, Number 1—January 2018
CME ACTIVITY - Synopsis
Zika Virus Testing and Outcomes during Pregnancy, Florida, USA, 2016
Table 5
Clinical and laboratory characteristics of 2 infants and their mothers who had laboratory evidence of Zika virus infection, Miami–Dade County, Florida, USA, 2016*
Characteristic | Case-infant 1 | Case-infant 2 |
---|---|---|
Country of exposure | Haiti | Venezuela |
Gestational age at time of symptoms |
≈10 wk (2015 Nov) |
≈12 wk (2015 Dec) |
Laboratory results for Zika virus | ||
Mother | Serum IgM neg (April 2016) | Serum neg rRT-PCR, pos IgM (2016 Apr) |
Infant |
Serum/CSF neg rRT-PCR, pos IgM, pos PRNT >10 Zika virus (2016 May) |
Serum/CSF/CB neg rRT-PCR, pos IgM (2016 Jun) |
Antenatal ultrasound | HC <3%, BPD <3% (33.1 WGA) | HC 10%, BPD 34% (36.4 WGA) |
HC at birth |
30.5 cm (<1%) |
34 cm (25%–50%) |
Postnatal cranial imaging |
Serpiginous calcifications, R; polymicrogyriccortex, BL; simplified gyral pattern (BL, L >R) |
Linear calcifications, L; polymicrogyric cortex, R; atrophy cerebral peduncle, R; overall volume loss of entire brain, R >L |
Ocular evaluation | Unremarkable | Hypopigmented R superior retinal lesion |
Auditory evaluation | Unremarkable | Normal |
*BL, bilateral ; BPD, biparietal diameter; CSF, cerebrospinal fluid; HC, head circumference; L, left; neg, negative; pos, positive; PRNT, plague-reduction neutralization test; R, right; rRT-PCR, real-time reverse transcription PCR; WGA, weeks gestational age.
1These authors contributed equally to this article.