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CDC EID journal Volume 24 Number 1—January 2018 Main Article

Volume 24, Number 1—January 2018

Research

Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia

Alex Y.C. TaiComments to Author , Eugene Athan, N. Deborah Friedman, Andrew Hughes, Aaron Walton, and Daniel P. O’Brien
Author affiliations: Barwon Health, Geelong, Victoria, Australia

Main Article

Table 2

Logistic regression analysis of adjusted and unadjusted associations between patient characteristics and severe Mycobacterium ulcerans disease, Barwon Health Cohort, Geelong, Victoria, Australia, January 1998–May 2017*

Characteristic Nonsevere disease, no. (%) Severe disease, no. (%) Crude odds ratio (95% CI) p value Adjusted odds ratio (95% CI) p value
Age, y
≤15 31 (77.5) 9 (22.5) 1.62 (0.71–3.71) 0. 004 1.73 (0.73–4.12) 0.006
16–64 184 (84.8) 33 (15.2) 1 1
≥65
 120 (71.0)
 49 (29.0)
 2.28 (1.38–3.75)
2.34 (1.38–3.98)
Sex
F 156 (79.6) 40 (20.4) 1 0.66 1 0.51
M
 179 (77.8)
 51 (22.2)
 1.11 (0.70–1.77
1.18 (0.72–1.94)
Location
Mornington Peninsula 72 (70.6) 30 (29.4) 1 0.03 1 0.24
Bellarine Peninsula
 263 (81.2)
 61 (18.8)
 0.56 (0.33–0.93)
0.71 (0.40–1.26)
Lesion over a joint
No 228 (84.4) 42 (15.6) 1 <0.001 1 <0.001
Yes
 107 (68.6)
 49 (31.4)
 2.67 (1.64–4.36)
2.71 (1.65–4.43)
Time period
1998–2004 29 (85.3) 5 (14.7) 1 0.01 1 0.03
2005–2010 85 (87.6) 12 (12.4) 0.82 (0.27–2.52) 0.88 (0.28–2.80)
2011–2017
 221 (74.9)
 74 (25.1)
 1.94 (0.73–5.20)
2.11 (0.74–5.99)
Duration of symptoms before diagnosis, d
≤75 241 (77.7) 69 (22.3) 1 0.76 NA NA
>75 81 (81.0) 19 (19.0) 0.82 (0.46–1.44)
Missing
 13 (81.3)
 3(18.8)
 0.81 (0.22–2.91)
Diabetes mellitus
No 312 (79.8) 79 (20.2) 1 0.06 1 0.14
Yes
 23 (65.7)
 12 (34.3)
 2.06 (0.98–4.32)
1.86 (0.82–4.23)
Immune suppression
No 310 (79.3) 81 (20.7) 1 0.31 NA NA
Yes 25 (71.4) 10 (28.6) 1.50 (0.69–3.27)

*Adjusted for age, sex, location, position of lesion over a joint, time period, and diabetes mellitus. NA, not applicable.

Main Article

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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