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Volume 24, Number 1—January 2018

Research

Increased Severity and Spread of Mycobacterium ulcerans, Southeastern Australia

Alex Y.C. TaiComments to Author , Eugene Athan, N. Deborah Friedman, Andrew Hughes, Aaron Walton, and Daniel P. O’Brien
Author affiliations: Barwon Health, Geelong, Victoria, Australia

Main Article

Table 2

Logistic regression analysis of adjusted and unadjusted associations between patient characteristics and severe Mycobacterium ulcerans disease, Barwon Health Cohort, Geelong, Victoria, Australia, January 1998–May 2017*

Characteristic Nonsevere disease, no. (%) Severe disease, no. (%) Crude odds ratio (95% CI) p value Adjusted odds ratio (95% CI) p value
Age, y
≤15 31 (77.5) 9 (22.5) 1.62 (0.71–3.71) 0. 004 1.73 (0.73–4.12) 0.006
16–64 184 (84.8) 33 (15.2) 1 1
≥65
120 (71.0)
49 (29.0)
2.28 (1.38–3.75)

2.34 (1.38–3.98)

Sex
F 156 (79.6) 40 (20.4) 1 0.66 1 0.51
M
179 (77.8)
51 (22.2)
1.11 (0.70–1.77

1.18 (0.72–1.94)

Location
Mornington Peninsula 72 (70.6) 30 (29.4) 1 0.03 1 0.24
Bellarine Peninsula
263 (81.2)
61 (18.8)
0.56 (0.33–0.93)

0.71 (0.40–1.26)

Lesion over a joint
No 228 (84.4) 42 (15.6) 1 <0.001 1 <0.001
Yes
107 (68.6)
49 (31.4)
2.67 (1.64–4.36)

2.71 (1.65–4.43)

Time period
1998–2004 29 (85.3) 5 (14.7) 1 0.01 1 0.03
2005–2010 85 (87.6) 12 (12.4) 0.82 (0.27–2.52) 0.88 (0.28–2.80)
2011–2017
221 (74.9)
74 (25.1)
1.94 (0.73–5.20)

2.11 (0.74–5.99)

Duration of symptoms before diagnosis, d
≤75 241 (77.7) 69 (22.3) 1 0.76 NA NA
>75 81 (81.0) 19 (19.0) 0.82 (0.46–1.44)
Missing
13 (81.3)
3(18.8)
0.81 (0.22–2.91)



Diabetes mellitus
No 312 (79.8) 79 (20.2) 1 0.06 1 0.14
Yes
23 (65.7)
12 (34.3)
2.06 (0.98–4.32)

1.86 (0.82–4.23)

Immune suppression
No 310 (79.3) 81 (20.7) 1 0.31 NA NA
Yes 25 (71.4) 10 (28.6) 1.50 (0.69–3.27)

*Adjusted for age, sex, location, position of lesion over a joint, time period, and diabetes mellitus. NA, not applicable.

Main Article

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