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Volume 24, Number 1—January 2018

Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Vincent C.C. Cheng1, Siddharth Sridhar1, Shuk-Ching Wong, Sally C.Y. Wong, Jasper F.W. Chan, Cyril C.Y. Yip, Chi-Hung Chau, Timmy W.K. Au, Yu-Yan Hwang, Carol S.W. Yau, Janice Y.C. Lo, Cheuk-Kwong Lee, and Kwok-Yung YuenComments to Author 
Author affiliations: University of Hong Kong, Hong Kong (V.C.C. Cheng, S. Sridhar, S.C.Y. Wong, J.F.W. Chan, C.C.Y. Yip, K.-Y. Yuen); Queen Mary Hospital, Hong Kong (V.C.C. Cheng, S.-C. Wong, T.W.K. Au, Y.-Y. Hwang); Grantham Hospital, Hong Kong (C.-H. Chau); Centre for Health Protection, Hong Kong (C.S.W. Yau, J.Y.C. Lo); Hong Kong Red Cross Blood Transfusion Service, Hong Kong (C.-K. Lee)

Main Article


Demographics, investigation results, and clinical details of asymptomatic JEV-infected blood donor and recipients, Hong Kong, China, May‒July 2017*

Variable Donor Packed red blood cell recipient (index patient) Platelet recipient Plasma recipient
Underlying disease
No history of disease, no recent travel to JEV-endemic regions outside Hong Kong; resides in JEV-endemic area Tin Shui Wai, Yuen Long
End-stage chronic obstructive pulmonary disease with lung transplantation, May 10
Acute myeloid leukemia post induction chemotherapy with cytarabine and daunorubicin
Intracranial hemorrhage
Blood donation or transfusion type, date
Blood donation, May 29
Packed red blood cell transfusion, June 22
Platelet transfusion, June 2
Plasma transfusion, June 20
Pretransfusion IgM serology result, date
Specimen not available
Serum negative, May 31
Serum negative, May 25
Specimen not available
Posttransfusion IgM serology result, date
Serum positive, July 22
CSF positive, July 11; serum positive, July 15 and 18
Serum positive, July 5 and 22
Specimen not available
JEV nucleic acid test, specimen type and result, date
Positive archived blood specimen
Positive blood sample, June 26 and 28; positive bronchoalveolar lavage, July 10
Negative plasma sample, July 22; negative urine sample, July 25
Specimen not available
Clinical symptoms
Fever and rash July 6 (14 d after transfusion), followed by decreased consciousness and myoclonic jerks; MRI showed typical appearance of T2 hyperintensity of bilateral thalami, substantia nigra, and medial temporal lobes
Outcome Full recovery Died October 1, 2017 Full recovery Died from respiratory failure 14 d after transfusion

*CSF, cerebrospinal fluid; JEV, Japanese encephalitis virus; MRI, magnetic resonance imaging.

Main Article

1These authors contributed equally to this article.

Page created: December 19, 2017
Page updated: December 19, 2017
Page reviewed: December 19, 2017
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